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The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

New effective scar treatments are urgently needed due to the current options' limited success.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Tributyltin exposure causes sex changes, sterilization, and decline in the snail Ocinebrina aciculata, risking its extinction.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

Masculine facial features may not reliably indicate heritable health, and more research is needed.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Probiotic bacteria improved skin and hair health in aged mice.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Most women with PCOS have high levels of male hormones, and free testosterone is the best marker for this.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Women with PCOS are more than twice as likely to develop nonalcoholic fatty liver disease.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

An mFG score of 5 or more indicates above-normal hair growth in Southern Chinese women.