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    Glossary Peroxisome Proliferator-Activated Receptors

    regulate gene expression related to metabolism and inflammation

    Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. They play crucial roles in the metabolism of fats and sugars, inflammation, and cell differentiation, making them significant in conditions like diabetes, obesity, and cardiovascular diseases.

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    Research 30 of 847

    1. Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist Archives of dermatology · 2009 · 105 citations
    2. Lichen planopilaris treated by the peroxisome proliferator activated receptor-γ agonist pioglitazone: Lack of lasting improvement or cure in the majority of patients Journal of The American Academy of Dermatology · 2013 · 33 citations
    3. Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics? Archives of dermatological research · 2015 · 60 citations
    4. Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells’ mitochondrial function via sonic hedgehog signaling Burns & Trauma · 2025 · 5 citations
    5. Functions of peroxisome proliferator‐activated receptors (PPAR) in skin homeostasis Lipids · 2004 · 46 citations
    6. Peroxisome Proliferator Activated Receptors Gamma Serum levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case Control Study Research Square (Research Square) · 2022
    7. 223 Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor γ Isoforms are Differentially Expressed in Human Skin and Skin Appendages 2022
    8. Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample Benha Journal of Applied Sciences · 2023
    9. PPAR-<i>γ</i> Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017 · 38 citations
    10. A Review of Metabolic Dysregulation in Lymphocytic Cicatricial Alopecia: Exploring the Connections and Therapeutic Implications Journal of Investigative Dermatology · 2025 · 1 citations
    11. Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris Journal of Investigative Dermatology · 2017 · 71 citations
    12. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018 · 80 citations
    13. The role of PPAR<i>γ</i>-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology Experimental Dermatology · 2015 · 84 citations
    14. Faculty Opinions recommendation of Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    15. Peroxisome Proliferator–Activated Receptor-γ−Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium Journal of Investigative Dermatology · 2018 · 17 citations
    16. Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease BioMolecular Concepts · 2012 · 12 citations
    17. Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth Acta dermato-venereologica · 2000 · 51 citations
    18. The role of nuclear hormone receptors in cutaneous wound repair Cell Biochemistry and Function · 2014 · 68 citations
    19. Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors Journal of Endocrinology and Reproduction · 2023
    20. Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances Pharmacological Research · 2019 · 112 citations
    21. Treatment of frontal fibrosing alopecia and lichen planopilaris: a systematic review Journal of the European Academy of Dermatology and Venereology · 2013 · 117 citations
    22. 4-<i>O</i>-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling Biomolecules & Therapeutics · 2017 · 5 citations
    23. Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk Genes & Development · 2007 · 102 citations
    24. The Role of MicroRNA, Long Non-Coding RNA and Circular RNA in the Pathogenesis of Polycystic Ovary Syndrome: A Literature Review International journal of molecular sciences · 2024 · 1 citations
    25. Roles of Wnt7a in embryo development, tissue homeostasis, and human diseases Journal of Cellular Biochemistry · 2019 · 16 citations
    26. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled EMBO journal · 2002 · 127 citations
    27. Clinical Pathobiology of Radiotherapy-Induced Alopecia: A Guide toward More Effective Prevention and Hair Follicle Repair 2023 · 3 citations
    28. Immune and Non-immune Interactions in the Pathogenesis of Androgenetic Alopecia Clinical Reviews in Allergy & Immunology · 2025
    29. Utilising SNP Association Analysis as a Prospective Approach for Personalising Androgenetic Alopecia Treatment Dermatology and therapy (Internet) · 2024
    30. Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets Pharmaceutical Research · 2025 · 2 citations