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The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Liquorice may reduce testosterone and affect male reproductive organs, potentially helping treat conditions like prostate cancer.

Urologic diseases and treatments in older men can negatively affect fertility, and doctors should talk to patients about this.

Flutamide-induced hypospadias in rats slows down early wound healing.

The chapter explains the causes of excessive hair growth and masculinization in women and how to measure hormone levels related to these conditions.

Father's finasteride use may affect son's fertility and testicular function.

Post-finasteride Syndrome causes lasting negative effects, but more research is needed for treatment and risk evaluation.

Cell transplantation faces challenges in genitourinary reconstruction, but alternative tissue sources and microencapsulation show promise.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.