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Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Costunolide may have multiple health benefits, including promoting hair growth and protecting against cancer and diabetes, but more research is needed.

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

Mutations in the DSG4 gene can cause a rare hair disorder similar to monilethrix.

LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.

Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Mercuric triflate is an effective catalyst for various organic reactions, working well at room temperature with high yields.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Advanced human skin models improve drug development and could replace animal testing.

Dermal papilla cells help wounds heal better and can potentially grow new hair.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

Hidradenitis suppurativa treatment should be tailored to the individual, with quitting smoking being important.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Most low-level light therapy studies did not accurately report how light was measured, affecting treatment reliability.

Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.

Mood stabilizers like lithium and anticonvulsants have side effects that can lead to patients stopping their medication, and managing these effects is important for treatment adherence.

Pregnancy often causes skin changes like darkening, stretch marks, and hair growth, which may improve after childbirth.

People with alopecia areata often have lower levels of vitamin D, zinc, and folate, but more research is needed to understand if supplements can help treat it.

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

Scientists found a way to grow human hair cells in a lab that can create new hair when transplanted.

PCOS symptoms change with age; younger women have higher androgen levels and less metabolic issues, while older women face more metabolic challenges despite milder PCOS symptoms.

Genetic screening is crucial for accurately diagnosing APS-1 due to its varied symptoms.