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    Glossary PADI3

    enzyme crucial for hair shaft formation and maintenance

    PADI3 stands for Peptidyl Arginine Deiminase, Type III, an enzyme that plays a crucial role in the formation and maintenance of hair. It modifies certain proteins in hair follicles, which is essential for proper hair shaft formation. Mutations in the PADI3 gene can lead to hair disorders such as uncombable hair syndrome, characterized by dry, frizzy hair that is resistant to being combed flat.

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    Research 30 of 467

    1. A Hairy Cituation – PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    2. Co-expression of PADI isoforms during progenitor differentiation enables functional diversity Philosophical Transactions of the Royal Society B Biological Sciences · 2023 · 2 citations
    3. The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles Science Advances · 2025
    4. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    5. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
    6. Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 49 citations
    7. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    8. Genetic Susceptibility to Alopecia The New England Journal of Medicine · 2019 · 5 citations
    9. Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles BMC Dermatology · 2020 · 4 citations
    10. Two siblings with uncombable hair syndrome: A new pathogenic variant Pediatric Dermatology · 2024 · 2 citations
    11. Deimination in epidermal barrier and hair formation Philosophical transactions - Royal Society. Biological sciences · 2023 · 2 citations
    12. Pili trianguli et canaliculi as a phenotypic subtype in patients with central centrifugal cicatricial alopecia: A scanning electron microscopy study Journal of the American Academy of Dermatology · 2020 · 2 citations
    13. Ugreelig hår Tidsskrift for Den norske legeforening · 2022 · 1 citations
    14. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2025
    15. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia. PubMed · 2025
    16. 481 Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2024
    17. Uncombable hair syndrome and beyond Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.) · 2022
    18. Unravelling the threads of central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2026
    19. Central centrifugal cicatricial alopecia: a subtype of lichen planopilaris in African descent? Portuguese Journal of Dermatology and Venereology · 2024
    20. Support for dermatological research in Sub‐Saharan Africa: insights from African hair and skin research programs International Journal of Dermatology · 2024
    21. This month in JAAD Case Reports: October 2023—Central centrifugal cicatricial alopecia in Black men Journal of the American Academy of Dermatology · 2023
    22. Uncombable hair syndrome due to maternal uniparental disomy of chromosome 1 American journal of medical genetics. Part A · 2022
    23. Central Centrifugal Cicatricial Alopecia (CCCA) CRC Press eBooks · 2021
    24. Deciphering the pathogenesis of central centrifugal cicatricial alopecia 2019
    25. 284 Deciphering the pathogenesis of central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2019
    26. Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin 2000 · 124 citations
    27. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005 · 71 citations
    28. Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer 2007 · 62 citations
    29. Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles Biological & pharmaceutical bulletin · 2017 · 4 citations
    30. Citrullination at the Inflammatory Skin Barrier 2023