May 2026 in “Nature Communications” In this study, researchers identified that keloid fibroblasts respond to neurotransmitters from catecholaminergic nerves by producing bone matrix proteins, mediated by β1-adrenergic receptor activation, leading to fibro-osseous reprogramming; blocking this signaling in a rodent model prevented the development of keloid-like pathology.
11 citations
,
November 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study found that bolandiol increased lean body mass and bone mineral density in castrate adult male rats, exhibiting tissue selectivity and acting through multiple receptor pathways with less potency compared to other androgens.
3 citations
,
January 2018 in “Reproduction, Fertility and Development” This study concluded that cyproterone acetate alone produced antiandrogenic effects on the female gerbil prostate, while ethinyloestradiol alone stimulated estrogenic activity, and their combination led to prostatic lesions.
37 citations
,
September 2003 in “Journal of Medicinal Chemistry” This study found that compound 2g inhibits steroid sulfatase effectively without exhibiting estrogenic activity, making it a promising candidate for breast cancer treatment.
25 citations
,
May 2021 in “Journal of exposure science & environmental epidemiology/Journal of exposure science and environmental epidemiology” This study found that hair products commonly used by Black women exhibited hormonal activity, which could impact health outcomes and contribute to health disparities.
11 citations
,
August 2019 in “Journal of Molecular Histology” This study found that upregulation of NFIC may enhance proliferation and osteogenic/cementogenic differentiation in rat dental follicle cells.
2 citations
,
May 2021 in “International journal of molecular sciences” This study demonstrated that autologous mesenchymal stem cells from hair follicles, when combined with a novel gelatin-based hydrogel, showed promising osteogenic potential and could offer a non-invasive alternative for bone regeneration.
2 citations
,
November 2019 in “FEBS open bio” This study found that stimulating dermal papilla cells with specific adipo-osteogenic factors and growth factors helped maintain their viability and restored their hair-forming activity in vitro.
6 citations
,
August 2020 in “Cell regeneration” This study found that hair follicle mesenchymal stem cells are similar to bone marrow stem cells in most characteristics, but differ in their adipogenic and osteogenic differentiation capabilities, suggesting they may be a suitable source for adipogenesis research.
19 citations
,
August 2014 in “Journal of Ethnopharmacology” The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.
17 citations
,
December 2004 in “Bioorganic & Medicinal Chemistry Letters” This study identified N-acyl arylsulfonamides, particularly N-(Boc-piperidine-4-carbonyl)-benzenesulfonamides, as steroid sulfatase inhibitors with improved cellular potency compared to previous compounds.
28 citations
,
September 2020 in “Pharmaceutics” This review discusses the potential of three-dimensional printed mesoporous scaffolds for drug delivery applications, particularly for bone cells and tissues, but reports no new clinical results.
13 citations
,
April 2002 in “International Journal of Toxicology” This review discusses the use of human and animal-derived placental and umbilical extracts in cosmetics, highlighting insufficient data to establish their safety and recommending they should not have metabolic or endocrine activity.
2 citations
,
September 2025 in “Frontiers in Endocrinology” This review critically evaluates the evidence for SARMs' tissue selectivity and suggests their clinical benefits over traditional androgens are not yet well-supported by robust evidence, underscoring the need for further head-to-head trials.
2 citations
,
October 2021 in “Exploration of targeted anti-tumor therapy” This review describes oncotherapy-induced alopecia in patients receiving hormone therapy for hormone-receptor-positive breast cancer and concludes that topical hormones should not be used due to oncogenic potential.
2 citations
,
May 2020 in “Journal of the American Academy of Dermatology” This study suggests that higher use of phytoestrogen-containing hair and personal care products may increase the association between permanent hair dye, straightener use, and breast cancer risk in black women.
2 citations
,
April 2018 in “Natural Product Communications” This review summarizes the bioactive compounds and pharmacological functions of Cynomorium songaricum Rupr., emphasizing its potential in developing health-related products, and notes that further research is needed.
April 2026 in “microPublication” In this study, researchers explored whether minoxidil, a common treatment for androgenetic alopecia, may have estrogenic activity and found preliminary evidence suggesting it could act as a partial agonist of Estrogen Receptor α (ERα).
In this review, the authors highlight that drugs promoting androgenic activity or inhibiting estrogenic activity may unmask or worsen androgenetic alopecia in genetically predisposed individuals, indicating the need for careful management in clinical settings.
This paper introduces a framework attributing Post-SSRI, Post-Finasteride, Post-Retinoid, and an unnamed sexual dysfunction syndrome to downregulated estrogen receptor activity, potentially guiding future treatments in sexual medicine.
This study developed a new analytical method to identify a wide range of endocrine disrupting compounds in full-term amniotic fluid, revealing diverse substances with potential endocrine activity.
16 citations
,
October 1996 in “PubMed” This study concluded that hormonal replacement therapy can improve skin ageing symptoms by increasing skin thickness and alleviating dryness and hyposeborrhoea in postmenopausal women.
40 citations
,
March 1982 in “British Journal of Dermatology” This study found that women experiencing diffuse hair loss had significantly lower levels of plasma sex-hormone binding globulin compared to controls, while their testosterone levels remained normal.
9 citations
,
July 2021 in “Essays in Biochemistry” This review discusses the roles of steroid hormone receptors in lung function related to COVID-19 and outlines ongoing clinical trials of steroid receptor ligands, but reports no new results.
This study developed a three-dimensional model for studying hair follicle development, showing that immortalized dermal papilla cells retain certain differentiation activities and can induce tubule formation in vitro.
28 citations
,
March 2010 in “Histochemistry and cell biology” Skin cells can help create early hair-like structures in lab cultures.
11 citations
,
December 2018 in “Bone” This study found that a high-energy shock wave can increase osteogenic activities in human mesenchymal cells, offering insights into potential therapeutic targets for trauma-induced heterotopic ossification.
27 citations
,
October 2011 in “British Journal of Dermatology” This study builds on previous findings by associating female pattern hair loss with gene polymorphisms related to oestrogen activity, suggesting oestrogen's role in the condition.
January 2025 in “Journal of Pharmacognosy and Phytochemistry” In this study, the researchers investigated the plant Vitex negundo and its active ingredients, noting that both natural and synthetic derivatives exhibit concentrated biological activity, which may explain the plant's traditional use in treating various ailments such as depression, malaria, and skin diseases.
September 2022 in “Institutional Repositories DataBase (IRDB)” Adipose-derived stem cells can be transformed into hair-forming cells using specific extracellular vesicles, offering potential for hair regeneration therapies.