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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.

Some hormone treatments might raise breast cancer risk, while others don't seem to.

The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.

Anti-androgens can help reduce the effects of male hormones on the skin.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

Aromatase inhibitor therapy for breast cancer increases the risk of hair loss and thinning.

Australian doctors experienced in adult transgender healthcare mostly prescribe intramuscular testosterone and oral estradiol, recommend mental health assessments before hormone therapy, and support improved training and guidelines.

Testosterone therapy seems safe for short-term use in postmenopausal women with low sexual desire, but more research on long-term effects is needed.

Some breast cancer patients on hormone therapy experience hair loss, and treatments like certain topical inhibitors and supplements may help without harming their cancer prognosis.

A breast cancer patient had lasting hair loss after chemotherapy, which improved with minoxidil treatment.

Hormone therapy for breast cancer often leads to sexual issues like vaginal dryness and decreased libido.

The document concludes that non-binary individuals need compassionate support and recognition in healthcare, without being pathologized.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Some birth control pills have a higher risk of blood clots than others.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Combining laser hair removal with topical eflornithine is recommended for better results in treating unwanted facial hair.

Suppressing certain hormones might help prevent prostate cancer.

Gemcitabine and paclitaxel are effective and safe as first-line treatment for metastatic breast cancer.

Testosterone replacement therapy should be used for men with low testosterone levels and symptoms of hypogonadism, after careful diagnosis and considering individual needs.

Men with frontal male pattern baldness may have a higher risk of gastric cancer.

Ciproterone acetate improves hair regrowth and acne in most female patients.

Gender identity can be more diverse than just male or female.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Hair loss treatments include medications and new methods like low-level light therapy, which may work by boosting cell activity and blood flow.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Hormonal treatments can improve acne, but they come with potential side effects and risks.