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    Glossary Neurosteroid Synthesis

    Neurosteroid synthesis refers to the production of steroid hormones within the brain and nervous system, which can influence various physiological processes, including mood, cognition, and stress response. In the context of hair loss, neurosteroids may play a role in modulating hair follicle biology and the hair growth cycle, particularly through their effects on androgen receptors and local hormonal balance. Key distinguishing characteristics of neurosteroids include their ability to rapidly affect neuronal function and their synthesis from cholesterol or other steroid precursors within the central nervous system.

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    Research 30 of 398

    1. Neurosteroid Synthesis-Mediated Regulation of GABA<sub>A</sub>Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007 · 238 citations
    2. Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep Neuroscience · 2007 · 100 citations
    3. Temporal lobe epilepsy exacerbation during pharmacological inhibition of endogenous neurosteroid synthesis BMJ Case Reports · 2013 · 13 citations
    4. Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis Frontiers in Cellular Neuroscience · 2015 · 11 citations
    5. Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis Journal of Neuroendocrinology · 2024 · 7 citations
    6. Mitochondrial dysfunction in diabetic neuropathy may be involved in the development of neuropathic pain via a reduction in neurosteroid synthesis F1000Research · 2017 · 4 citations
    7. Mitochondrial dysfunction in an animal model of diabetic neuropathy is associated with a reduction of neurosteroid synthesis. F1000Research · 2018 · 1 citations
    8. Neo-synthesis of estrogenic or androgenic neurosteroids determine whether long-term potentiation or depression is induced in hippocampus of male rat Frontiers in Cellular Neuroscience · 2015 · 32 citations
    9. Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress Schizophrenia Research · 2015 · 24 citations
    10. Early postnatal inhibition of neurosteroid synthesis changes the later-life adverse outcome of neonatal asphyxia in rats Neuropharmacology · 2025
    11. 11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis Neuropharmacology · 2011 · 18 citations
    12. Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    13. The effect of finasteride and dutasteride on the synthesis of neurosteroids by glioblastoma cells Steroids · 2019 · 19 citations
    14. Cerebellar Changes in Guinea Pig Offspring Following Suppression of Neurosteroid Synthesis During Late Gestation The Cerebellum · 2016 · 9 citations
    15. Effect of Neurosteroids on Basal and Stress-Induced Oxytocin Secretion in Luteal-Phase and Pregnant Sheep Animals · 2023
    16. Ruolo dei neurosteroidi nella modulazione dopaminergica 2015
    17. Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity Frontiers in Cellular Neuroscience · 2026
    18. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression Korean Journal of Urology · 2014 · 75 citations
    19. Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain Pain · 2011 · 61 citations
    20. Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates General and Comparative Endocrinology · 2020 · 21 citations
    21. Signal Detection of Depression and Suicidality Associated with Finasteride and Dutasteride: Updated Pharmacovigilance Evidence and Recommendations for Comprehensive Psychiatric Assessment Brain Sciences · 2026
    22. Finasteride-Induced Neuropsychiatric Reactions Journal of Dermatology and Skin Science · 2026
    23. Inhibitory influence of agmatine on catamenial-like seizure susceptibility in progesterone withdrawn female rats Brain disorders · 2024
    24. Neurosteroids on the Epilepsy Chessboard—Keeping Seizures in Check Epilepsy Currents · 2010
    25. 5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes NeuroSci · 2026
    26. Role of neurosteroids in the anticonvulsant activity of midazolam British Journal of Pharmacology · 2011 · 28 citations
    27. Involvement of neurosteroids in the control of hypothalamic-pituitary-adrenal axis activity in pregnant sheep under basal and stressful conditions Theriogenology · 2021 · 4 citations
    28. Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain Neuroscience · 2009 · 76 citations
    29. Neurosteroid-sensitive δ-GABA<sub>A</sub>receptors: A role in epileptogenesis? Epilepsia · 2017 · 20 citations
    30. Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model Investigative Ophthalmology & Visual Science · 2014 · 31 citations