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    Glossary mTOR inhibitors

    block a protein that regulates cell growth and survival

    mTOR inhibitors, also known as mTOR blockers or mTOR antagonists, are a class of drugs that inhibit the activity of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, proliferation, and survival. By blocking mTOR, these inhibitors can slow down or stop the growth of cancer cells and are also being explored for their potential in treating other conditions like autoimmune diseases and certain types of hair loss, such as alopecia.

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    Research 30 of 1000+

    1. Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway Discovery medicine · 2023
    2. 976 Knockout of mTOR/Akt inhibitor REDD1 results in hair cycle-independent dermal adipose expansion by promoting adipocyte differentiation Journal of Investigative Dermatology · 2019
    3. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change Journal of experimental botany · 2013 · 161 citations
    4. Wedelolactone inhibits breast cancer-induced osteoclastogenesis by decreasing Akt/mTOR signaling International Journal of Oncology · 2014 · 53 citations
    5. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    6. 896 Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line Journal of Investigative Dermatology · 2019
    7. mTOR signaling in hair follicle and hair diseases: recent progress Frontiers in medicine · 2023
    8. Valproic acid boosts hair follicle stem cell resilience to oxygen-glucose deprivation through autophagy induction and AKT/mTOR suppression Scientific Reports · 2025
    9. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells Annals of Medicine · 2025
    10. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    11. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    12. Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails American Journal of Clinical Dermatology · 2018 · 179 citations
    13. Advances in the Management of Cutaneous Toxicities of Targeted Therapies Seminars in Oncology · 2012 · 42 citations
    14. Birt–Hogg–Dubé syndrome: from gene discovery to molecularly targeted therapies Familial cancer · 2012 · 39 citations
    15. Premature aging syndromes: From patients to mechanism Journal of dermatological science · 2019 · 29 citations
    16. Disruption of tubular Flcn expression as a mouse model for renal tumor induction Kidney International · 2015 · 29 citations
    17. PKC downregulation upon rapamycin treatment attenuates mitochondrial disease Nature metabolism · 2020 · 26 citations
    18. Patients with bullous skin disease in a high‐epidemic COVID‐19 area, Bergamo, Italy British Journal of Dermatology · 2020 · 17 citations
    19. Cutaneous Toxicities From Transplantation-Related Medications American Journal of Transplantation · 2017 · 14 citations
    20. Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy? PLoS ONE · 2014 · 12 citations
    21. Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives International Journal of Molecular Sciences · 2024 · 9 citations
    22. Birt–Hogg–Dubé syndrome Familial cancer · 2013 · 7 citations
    23. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    24. Dermatologic Care of the Transplant Patient Journal of the Dermatology Nurses’ Association · 2010 · 2 citations
    25. ТУБЕРОЗНЫЙ СКЛЕРОЗ (БУРНЕВИЛЛЯ-ПРИНГЛА). ОБЗОР ЛИТЕРАТУРЫ 2026
    26. Pathogenesis and management of TRPV3-related Olmsted syndrome Frontiers in Genetics · 2024
    27. 1370 MTORC1 activity is increased in the skin of acne patients and is suppressed with isotretinoin treatment Journal of Investigative Dermatology · 2023
    28. CAQ Corner: Basic concepts of transplant immunology Liver transplantation · 2022
    29. Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma International journal of dermatology and venereology · 2019
    30. Dermatologic Side Effects of Systemic Targeted Anticancer Therapy Springer eBooks · 2018