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    Glossary mTOR inhibitors

    block a protein that regulates cell growth and survival

    mTOR inhibitors, also known as mTOR blockers or mTOR antagonists, are a class of drugs that inhibit the activity of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, proliferation, and survival. By blocking mTOR, these inhibitors can slow down or stop the growth of cancer cells and are also being explored for their potential in treating other conditions like autoimmune diseases and certain types of hair loss, such as alopecia.

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    Research 30 of 1000+

    1. 976 Knockout of mTOR/Akt inhibitor REDD1 results in hair cycle-independent dermal adipose expansion by promoting adipocyte differentiation Journal of Investigative Dermatology · 2019
    2. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change Journal of experimental botany · 2013 · 161 citations
    3. Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis Theranostics · 2024
    4. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    5. mTOR signaling in hair follicle and hair diseases: recent progress Frontiers in medicine · 2023
    6. 896 Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line Journal of Investigative Dermatology · 2019
    7. Valproic acid boosts hair follicle stem cell resilience to oxygen-glucose deprivation through autophagy induction and AKT/mTOR suppression Scientific Reports · 2025
    8. High doses of cobalt inhibited hair follicle development in Rex Rabbits World rabbit science · 2019 · 1 citations
    9. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    10. Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy Stem Cell Research & Therapy · 2020 · 20 citations
    11. Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy 2020
    12. Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy Research Square (Research Square) · 2020
    13. Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy Research Square (Research Square) · 2020
    14. Low-Molecular-Weight Fish Collagen Peptide Enhances Hair Regrowth via Activation of Proliferative Signaling and Suppression of Inhibitory Pathways Marine Drugs · 2026
    15. Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails American Journal of Clinical Dermatology · 2018 · 179 citations
    16. Advances in the Management of Cutaneous Toxicities of Targeted Therapies Seminars in Oncology · 2012 · 42 citations
    17. Birt–Hogg–Dubé syndrome: from gene discovery to molecularly targeted therapies Familial cancer · 2012 · 39 citations
    18. Disruption of tubular Flcn expression as a mouse model for renal tumor induction Kidney International · 2015 · 29 citations
    19. Premature aging syndromes: From patients to mechanism Journal of dermatological science · 2019 · 29 citations
    20. PKC downregulation upon rapamycin treatment attenuates mitochondrial disease Nature metabolism · 2020 · 26 citations
    21. Patients with bullous skin disease in a high‐epidemic COVID‐19 area, Bergamo, Italy British Journal of Dermatology · 2020 · 17 citations
    22. Cutaneous Toxicities From Transplantation-Related Medications American Journal of Transplantation · 2017 · 14 citations
    23. Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy? PLoS ONE · 2014 · 12 citations
    24. Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives International Journal of Molecular Sciences · 2024 · 9 citations
    25. Birt–Hogg–Dubé syndrome Familial cancer · 2013 · 7 citations
    26. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    27. Dermatologic Care of the Transplant Patient Journal of the Dermatology Nurses’ Association · 2010 · 2 citations
    28. Editors' Picks Journal of Investigative Dermatology · 2013
    29. Pathogenesis and management of TRPV3-related Olmsted syndrome Frontiers in Genetics · 2024
    30. CAQ Corner: Basic concepts of transplant immunology Liver transplantation · 2022