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Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Different types of stem cells and their environments are key to skin repair and maintenance.

Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Fat cells in the skin help start healing and form important repair cells after injury.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

JAK inhibitors help with skin conditions but need more research on dosing and safety.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.

There are many treatments for permanent hair loss disorders, but their effectiveness varies and there's no clear best option.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.