109 citations
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April 1997 in “Journal of Lipid Research” This study found that pure linoleate deficiency in rats caused significant reductions in the accumulation of n-6 polyunsaturates and mild symptoms like growth retardation, compared to classical essential fatty acid deficiency.
June 2022 in “Authorea (Authorea)” This case report describes a 59-year-old Afro-American woman diagnosed with lipedematous alopecia, a rare scalp condition of unknown cause.
May 2026 in “International Research Journal of Ayurveda & Yoga” This review explores the Charaka samhita's concept of Ashtanindita purusha, identifying eight physical constitutions traditionally regarded as undesirable due to their association with various diseases, and aims to correlate these with contemporary genetic, endocrinological, and metabolic disorders.
This case report highlights that Tjalma Syndrome may present as a main symptom of systemic lupus erythematosus and should be considered in patients with ascites, pleural effusions, and elevated CA-125 levels.
16 citations
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July 2012 in “The New England Journal of Medicine” This case report describes a 27-year-old man hospitalized with fatigue, myalgias, weakness, profound weight loss, and abnormal liver function, leading to a diagnosis after chest imaging revealed pneumomediastinum.
30 citations
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January 1997 in “ILAR Journal” This review details the development and genetic background of senescence-accelerated mouse strains, provides a comprehensive examination of their phenotypes, and highlights their importance for aging research, but reports no new experimental results.
37 citations
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June 2000 in “Experimental dermatology” This study investigated a spontaneous mutation in mice resulting in hair abnormalities and elevated IgE levels, which resembles human Netherton's syndrome and monilethrix.
1 citations
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August 2000 in “Expert Opinion on Therapeutic Patents” This article reviews the therapeutic use of carnitine derivatives for re-establishing mitochondrial functionality in aging and reports no new clinical results.
April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, periodic exposure to red light in aged mice led to increased histone acetylation and activated mitochondrial fatty acid oxidation, which collectively mitigated cellular aging by modulating metabolism, inflammation, and gene expression.
July 2012 in “Alzheimer s & Dementia” This case report describes a 57-year-old Navy veteran with mild cognitive impairment who showed cognitive improvement and reported better mood after CPAP treatment and medication adjustments.
November 2024 in “Journal of Medical and Life Science” This case report describes a 33-year-old woman whose symptoms improved significantly after vitamin D and zinc supplementation, highlighting the importance of diagnosing and managing deficiencies to enhance quality of life in young women.
May 2025 in “The Journal of Rheumatology” This case report suggests that a proactive physical therapy model can be effective for improving physical function and meeting exercise guidelines in patients newly diagnosed with systemic lupus erythematosus.
May 2021 in “Journal of the Endocrine Society” This case study highlights the overlooked condition of opioid-induced adrenal insufficiency, emphasizing the need for increased clinician awareness of its potential prevalence in chronic opioid users.
139 citations
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December 2021 in “Journal of Clinical Medicine” This systematic review reports that fatigue was the most common symptom in both phases of long COVID, with lung function issues more frequent in the ongoing symptomatic phase and psychological burdens like anxiety and depression more prevalent in the post-COVID syndrome phase.
June 2020 in “International Journal of Research in Dermatology” In this study, xerosis was the most common skin condition found among elderly participants, followed by wrinkling and immunoglobulin heavy chain deposition.
November 2016 in “Journal of Evolution of Medical and Dental Sciences” This study observed that among elderly patients, the most common systemic disease associated with skin conditions was diabetes, while wrinkling and xerosis were prevalent skin changes.
29 citations
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December 2022 in “Dermatology and Therapy” This study reported that patients with alopecia areata experienced significant increases in work productivity loss and activity impairment due to worsening emotional symptoms, highlighting a need for better treatments.
6 citations
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December 2021 in “Journal of Clinical Medicine” This study introduced the Lichen Planus Activity and Damage Index (LiPADI), which effectively assesses the severity and progression of lichen planus, aligning well with other clinical indicators.
5 citations
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November 2020 in “EBioMedicine” This study reports a novel diagnostic method for latent circadian rhythm sleep-wake disorder using circadian gene oscillations from hair follicle cells to improve sleep disorder differentiation and potential therapeutic intervention.
12 citations
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October 2016 in “Patient Preference and Adherence” This study found that both patients and physicians expressed dissatisfaction with disease control in systemic lupus erythematosus, with patients showing greater dissatisfaction than physicians regarding symptoms.
2 citations
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August 2014 in “PubMed” This case report details a woman with postural orthostatic tachycardia syndrome who experienced notable dermatological symptoms, including evanescent hyperemia, which improved with the use of an oral angiotensin II type 1 receptor antagonist.
This study found that periodic red light exposure in aged mice increased histone acetylation and activated metabolic processes in keratinocytes, mitigating cellular aging through enhanced fatty acid oxidation and altered gene expression related to lipid metabolism.
In this retrospective cohort study of individuals diagnosed with late-onset systemic lupus erythematosus after age 80, most were women, joint and skin issues were prevalent, average survival was 4.5 years, and men had notably lower survival rates with higher mortality.
17 citations
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July 2014 in “Our Dermatology Online” In this study of elderly patients at an Indian medical center, researchers found that xerosis was the most common physiological skin change and pruritus was the most frequent complaint.
1 citations
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August 2025 in “Frontiers in Neuroscience” This review discusses cellular senescence in relation to ALS and explores how targeting senescent cells could potentially serve as a treatment strategy, but it reports no new clinical findings and emphasizes that this link is not yet conclusively established.
May 2026 in “Psychoneuroendocrinology” 10 citations
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April 2004 in “Journal of the American Academy of Dermatology” Localized hair growth and fat loss may share a common cause in lupus panniculitis.
1 citations
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October 2022 This article explores the overlap of Long Covid symptoms with various chronic fatigue syndromes and related conditions, discussing potential underlying mechanisms and proposing an integrated approach for managing these issues, but it reports no new clinical results.
21 citations
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February 2012 in “Journal of the European Academy of Dermatology and Venereology” This study found that late-onset alopecia areata is more common in women and tends to present with milder symptoms, with some patients achieving complete hair regrowth in mild cases.
May 2025 in “International Journal of Innovative Technologies in Social Science” This study found that regular caffeine consumption among medical students is linked to a higher risk of insomnia, with around 30% to nearly 50% of those surveyed reporting sleep disorders, and highlights the importance of health education on caffeine's side effects.