Decline of Life’s Energy Theory of Aging: Revitalization of Energy Metabolism and Aging Mitochondria

The document from 2000 examines the connection between the decline in mitochondrial energy production as animals age and the onset of age-related chronic conditions. It explores the use of carnitine derivatives, particularly acetyl-L-carnitine, in addressing issues with energy metabolism and potentially improving life quality during aging. The decline in mitochondrial functionality, decreased growth hormone secretion, and lower levels of mitochondrial components are linked to increased susceptibility to diseases such as cancer, cardiovascular diseases, and immune dysfunction. The role of growth hormone in mitochondrial function and the significance of cardiolipin in maintaining mitochondrial integrity for energy production are also discussed. The document reviews patents for nutraceutical compositions aimed at treating energy metabolism problems and rejuvenating aging mitochondria. It suggests that enhancing mitochondrial energy production with supplements like acetyl-L-carnitine could reverse age-related declines in cellular function and improve conditions like muscle and neural disorders, as well as potentially benefit hair growth and skin condition. However, the document does not specify the number of subjects in the studies it references.