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research Decline of life’s energy theory of ageing 1. Revitalisation of energy metabolism and ageing mitochondria

1 citations , August 2000 in “Expert Opinion on Therapeutic Patents”

This article reviews the therapeutic use of carnitine derivatives for re-establishing mitochondrial functionality in aging and reports no new clinical results.

research Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity

3 citations , January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that epidermolysis bullosa simplex keratinocytes had impaired mitochondrial activity and more dispersed mitochondrial distribution compared to normal human keratinocytes.

research 1408 Men’s skin needs energy for proper skin recovery & the combination of compounds A & B exhibits strong antioxidant and energy-amplifying benefits

April 2023 in “Journal of Investigative Dermatology”

In this study, the combination of two compounds activated AMPK levels in skin cells, reducing oxidative damage and improving energy production, which may support faster recovery and repair in aging skin.

research 1368 Does mitochondrial dysfunction drive immune privilege collapse in lichen planopilaris pathogenesis?

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that mitochondrial dysfunction might contribute to the pathogenesis of Lichen planopilaris by triggering a metabolic shift that leads to chronic inflammation and hair follicle damage.

research 15-Hydroxyprostaglandin Dehydrogenase Inhibitor Restores Endothelial Function Under Dihydrotestosterone-Induced Stress in Human Dermal Microvascular Endothelial Cells

December 2025 in “Molecules”

This study found that the 15-PGDH inhibitor DPP improved endothelial function in hair-related cells exposed to DHT by reducing oxidative stress and enhancing angiogenic capacity.

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community Claim: Insulin resistance increases the enzyme that creates DHT and affects the liver's ability to control hormones

in Research/Science 4 upvotes 11 months ago

Insulin resistance may increase DHT production, contributing to hair loss, and addressing it through diet, nutrients, and natural DHT blockers like saw palmetto and pumpkin seed oil could help reverse hair loss. Some users prefer medications like finasteride for more effective results.

community Thoughts on this topical? Has a combination going on but are they really heavy hitters

4 upvotes 7 months ago

Follicium XR™ is a topical treatment for hair loss containing RU58841, AHK-Cu, GHK-Cu Peptide, caffeine, D-Biotin, methylene blue, keratin, and spermidine. RU58841 is considered the most effective ingredient, but concerns exist about its stability in water.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

8 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community Does anyone here use coenzyme Q10 for hair loss?

in Chat 2 upvotes 5 months ago

The conversation is about using coenzyme Q10 for hair loss alongside dutasteride. The effectiveness of coenzyme Q10 for treating androgenetic alopecia is questioned due to a lack of evidence.

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