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    Glossary Label-Retaining Cells

    cells that divide infrequently and retain DNA labels

    Label-Retaining Cells (LRCs) are a type of cell that retains a DNA label over an extended period, indicating they divide infrequently. This characteristic is often used to identify stem cells or progenitor cells in tissues, including hair follicles, as these cells typically divide less frequently than other cell types, allowing them to maintain tissue homeostasis and regeneration.

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    1. Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis Development · 2003 · 421 citations
    2. Label Retaining Cells (LRCs) with Myoepithelial Characteristic from the Proximal Acinar Region Define Stem Cells in the Sweat Gland PLoS ONE · 2013 · 36 citations
    3. The Localization of Label-Retaining Cells in Eccrine Glands Journal of Investigative Dermatology · 2009 · 28 citations
    4. The Localization of Label-Retaining Cells in Mouse Nails Journal of Investigative Dermatology · 2007 · 22 citations
    5. Defining the Localization and Molecular Characteristic of Minor Salivary Gland Label-Retaining Cells Stem cells · 2014 · 18 citations
    6. Targeted elimination of the follicular label-retaining cells by photo-induced cell killing caused a defect on follicular renewal on mice Genes to Cells · 2002 · 8 citations
    7. Epithelial Stem Cells: Turning over New Leaves Cell · 2007 · 508 citations
    8. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    9. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007 · 153 citations
    10. Epidermal Stem Cells do not Communicate Through Gap Junctions Journal of Investigative Dermatology · 2002 · 73 citations
    11. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 72 citations
    12. Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells 2010 · 36 citations
    13. The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but not for Maintenance of the Epidermal Stem Cell Compartment 2008 · 25 citations
    14. The HPV16 oncogenes cause aberrant stem cell mobilization Virology · 2013 · 23 citations
    15. The Hair Follicle Bulge: A Niche for Adult Stem Cells Microscopy and Microanalysis · 2011 · 19 citations
    16. Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer EBioMedicine · 2019 · 13 citations
    17. Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice Cancer research · 2014
    18. Characterization of new stem/progenitor cells in skin appendages University of Southern California Digital Library · 2013
    19. Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion Cancer research · 2012
    20. Stem Cells and their Niches Journal of Investigative Dermatology · 2013 · 1 citations
    21. Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt<sup>WT</sup> mice Molecular carcinogenesis · 2013 · 8 citations
    22. Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia Histochemistry and Cell Biology · 2014 · 7 citations
    23. Developmental Plasticity of Patterned and Regenerating Oral Organs Current Topics in Developmental Biology · 2015 · 5 citations
    24. Molecular and Cellular Characterization of Avian Reticulate Scales Implies the Evo–Devo Novelty of Skin Appendages in Foot Sole Journal of developmental biology · 2023 · 1 citations
    25. Paneth Cells in Intestinal Homeostasis and Tissue Injury PLoS ONE · 2012 · 146 citations
    26. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage Journal of Cell Science · 1996 · 441 citations
    27. Lgr5 marks cycling, yet long-lived, hair follicle stem cells Nature Genetics · 2008 · 835 citations
    28. Dissecting the bulge in hair regeneration Journal of Clinical Investigation · 2012 · 86 citations
    29. Characterization of a new, inducible transgenic mouse model with GFP expression in melanocytes and their precursors Gene Expression Patterns · 2017 · 14 citations
    30. Ageratum Conyzoides L. Extract Inhibits 5α-Reductase Gene Expression and Prostaglandin D2 Release in Human Hair Dermal Papilla Cells and Improves Symptoms of Hair Loss in Otherwise Healthy Males and Females in an Open Label Pilot Study Journal of cosmetology & trichology · 2021