Search
for

    Did you mean Keratinocyte Growth Factor?
    Glossary Keratinocyte Growth Factor

    stimulates skin and hair cell growth and repair

    Keratinocyte Growth Factor (KGF), also known as Fibroblast Growth Factor 7 (FGF-7), is a protein that plays a crucial role in the growth and repair of skin and hair. It specifically stimulates the proliferation and differentiation of keratinocytes, which are the primary cells found in the outer layer of the skin and hair follicles. This makes KGF important in wound healing and potentially beneficial in treating conditions like alopecia.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    2. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. PubMed · 1995 · 219 citations
    3. Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair 2000 · 113 citations
    4. Keratinocyte Growth Inhibition through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells 2009 · 70 citations
    5. Specific receptor detection by a functional keratinocyte growth factor-immunoglobulin chimera. 1995 · 66 citations
    6. Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression The FASEB Journal · 2003 · 51 citations
    7. Strengthening the Skin with Topical Delivery of Keratinocyte Growth Factor-1 Using a Novel DNA Plasmid Molecular Therapy · 2014 · 23 citations
    8. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts Journal of dermatological science · 2019 · 20 citations
    9. Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD 71 (α6bri/CD71dim) Positive Keratinocyte Cells International Journal of Molecular Sciences · 2015 · 17 citations
    10. Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes Plastic and Reconstructive Surgery · 2007 · 16 citations
    11. Keratinocyte Growth Factor Modified Messenger RNA Accelerating Cell Proliferation and Migration of Keratinocytes Nucleic Acid Therapeutics · 2018 · 11 citations
    12. 15-deoxy prostaglandin J2, the nonenzymatic metabolite of prostaglandin D2, induces apoptosis in keratinocytes of human hair follicles: a possible explanation for prostaglandin D2-mediated inhibition of hair growth Naunyn-Schmiedeberg's Archives of Pharmacology · 2016 · 11 citations
    13. Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model Frontiers in Medicine · 2025 · 8 citations
    14. Production of a 135-residue long N-truncated human keratinocyte growth factor 1 in Escherichia coli Microbial Cell Factories · 2023 · 5 citations
    15. Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells Cosmetics · 2017 · 4 citations
    16. Expression and Cellular Localization of Keratinocyte Growth Factor and Its Receptor in Human Hyperplastic Prostate Tissue<sup>1</sup> The Journal of Clinical Endocrinology & Metabolism · 1998 · 4 citations
    17. Production of a 135-residue long N-truncated human keratinocyte growth factor 1 in Escherichia coli Research Square (Research Square) · 2022 · 2 citations
    18. A Nonrandomized Clinical Trial Investigating Keratinocyte Growth Factor‐Hair Serum for the Prevention of Chemotherapy‐Induced Alopecia Journal of Cosmetic Dermatology · 2026
    19. Research progress and strategies for the biosynthesis of keratinocyte growth factor-2 (KGF-2) in <i>Arabidopsis thaliana</i> PeerJ · 2025
    20. 557 Short-term Rho-associated kinase inhibitor treatment accelerates primary keratinocyte growth without affecting the characteristics of the stem cell population Journal of Investigative Dermatology · 2022
    21. Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds 2018
    22. Effects of recombinant human keratinocyte growth factor-2 on hair regeneration in experimental bald rats 2012
    23. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    24. Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles<i>in vitro</i> British Journal of Dermatology · 2014 · 60 citations
    25. 1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth 2023
    26. trans-3,4'-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor .BETA.2 (TGF-.BETA.2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes Biological and Pharmaceutical Bulletin · 2008 · 10 citations
    27. Hair Growth Promoting Effects of Kesh-Kanti-Expert-Oil are Mediated Through Keratinocyte Proliferation and Modulation in Follicular Microenvironment Pharmacological Research - Natural Products · 2025
    28. 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation 2018
    29. In vitro Hair Growth Promoting Effects of Naringenin and Hesperetin on Human Dermal Papilla Cells and Keratinocytes Journal of Dermatology and Venereology · 2017
    30. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes Molecular and Cellular Biology · 2006 · 226 citations