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    Did you mean Keratinocyte Growth Factor?
    Glossary Keratinocyte Growth Factor

    stimulates skin and hair cell growth and repair

    Keratinocyte Growth Factor (KGF), also known as Fibroblast Growth Factor 7 (FGF-7), is a protein that plays a crucial role in the growth and repair of skin and hair. It specifically stimulates the proliferation and differentiation of keratinocytes, which are the primary cells found in the outer layer of the skin and hair follicles. This makes KGF important in wound healing and potentially beneficial in treating conditions like alopecia.

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    1. Strengthening the Skin with Topical Delivery of Keratinocyte Growth Factor-1 Using a Novel DNA Plasmid Molecular Therapy · 2014 · 23 citations
    2. Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model Frontiers in Medicine · 2025 · 8 citations
    3. Production of a 135-residue long N-truncated human keratinocyte growth factor 1 in Escherichia coli Microbial Cell Factories · 2023 · 5 citations
    4. Production of a 135-residue long N-truncated human keratinocyte growth factor 1 in Escherichia coli Research Square (Research Square) · 2022 · 2 citations
    5. Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles<i>in vitro</i> British Journal of Dermatology · 2014 · 60 citations
    6. Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds 2018
    7. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts Journal of dermatological science · 2019 · 20 citations
    8. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    9. Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes Plastic and Reconstructive Surgery · 2007 · 16 citations
    10. Growth Differentiation Factor 11 (GDF11)/Transforming Growth Factor - β (TGF - β)/Mesenchymal Stem Cells (MSCs) Balance: A Complicated Partnership in Skin Rejuvenation Journal of Embryology & Stem Cell Research · 2019 · 1 citations
    11. 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation 2018
    12. Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839 Journal of the American Academy of Dermatology · 2004 · 1 citations
    13. l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase 2009 · 34 citations
    14. The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse Experimental dermatology · 2015 · 10 citations
    15. Growth factor mimetics for skin regeneration: In vitro profiling of primary human fibroblasts and keratinocytes Archiv der Pharmazie · 2021 · 3 citations
    16. Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus Medical records-international medical journal · 2023
    17. Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells PLoS ONE · 2011 · 39 citations
    18. Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed 2021 · 17 citations
    19. Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 8 citations
    20. Fibroblast Growth Factor-7 and Hair Biology: Bridging Basic Science and Therapeutic Applications Current Issues in Molecular Biology · 2026
    21. Astragalus membranaceus and Cinnamomum cassia Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt/β-Catenin Signaling Pathway Current Issues in Molecular Biology · 2023
    22. The Study of Growth Factors in Patients with Androgenic Alopecia Biomedical and Pharmacology Journal · 2017 · 7 citations
    23. The Role of the VEGF, KGF, EGF, and TGF-β1 Growth Factors in the Pathogenesis of Telogen Effluvium in Women Biomedical and Pharmacology Journal · 2017 · 5 citations
    24. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    25. Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice American Journal Of Pathology · 2008 · 55 citations
    26. Lymphoid Enhancer-binding Factor-1 (LEF1) Interacts with the DNA-binding Domain of the Vitamin D Receptor Journal of Biological Chemistry · 2011 · 37 citations
    27. A ‘hot’ new twist to hair biology – involvement of vanilloid receptor‐1 signaling in human hair growth control Experimental Dermatology · 2004 · 2 citations
    28. Attenuation of Dickkopf 1-Induced Hair Growth Inhibition in Cultured Human Hair Follicles by Tianeptine Annals of Dermatology · 2017 · 4 citations
    29. Impaired Keratinocyte Proliferative and Clonogenic Potential in Transgenic Mice Overexpressing 14-3-3σ in the Epidermis Journal of Investigative Dermatology · 2011 · 15 citations
    30. 1049 Novel strategy to promote hair follicle growth and stem cell activation in human male scalp skin: Targeting prolactin receptor with ABS-201 Journal of Investigative Dermatology · 2026