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    Glossary Intermediate Hairs

    hairs transitioning between fine vellus and thick terminal types

    Intermediate hairs are a type of hair that falls between vellus hairs (fine, short, and lightly pigmented) and terminal hairs (thick, long, and heavily pigmented). These hairs are typically found in areas undergoing a transition, such as during puberty or in certain stages of hair growth cycles, and they exhibit characteristics of both vellus and terminal hairs. For example, they may be longer and more pigmented than vellus hairs but not as coarse or dark as terminal hairs.

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    1. Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene. The EMBO Journal · 1990 · 93 citations
    2. Intermediate hair follicles: a new more clinically relevant model for hair growth investigations British Journal of Dermatology · 2010 · 30 citations
    3. Invited Discussion: Eyebrow Reconstruction With Intermediate Hair From the Hairline of the Forehead on the Pedicled Temporoparietal Fascial Flap Annals of Plastic Surgery · 2003 · 2 citations
    4. Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype Nutrients · 2022
    5. Isolation of intermediate filament assemblies from human hair follicles. The Journal of Cell Biology · 1985 · 28 citations
    6. Carbon-13 n.m.r. studies of keratin intermediate filament of human hair Polymer · 1998 · 5 citations
    7. Single-Cell Transcriptomic Identification of a Proliferative Intermediate State During Early Anagen Hair Follicle Regeneration Genes · 2026
    8. Complete sequence of a hair-like intermediate filament type II keratin gene DNA sequence · 1993 · 15 citations
    9. Trichohyalin, an intermediate filament-associated protein of the hair follicle. 1986 · 116 citations
    10. Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family Development · 1992 · 65 citations
    11. The role of disulfide bond formation in the structural transition observed in the intermediate filaments of developing hair Journal of Structural Biology · 2012 · 39 citations
    12. Regulation of a hair follicle keratin intermediate filament gene promoter Journal of Cell Science · 1998 · 39 citations
    13. In vivo formation steps of the hard α-keratin intermediate filament along a hair follicle: Evidence for structural polymorphism Journal of Structural Biology · 2006 · 22 citations
    14. Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation Journal of Structural Biology · 2006 · 19 citations
    15. Structure of intermediate filament assembly in hair deduced from hydration studies using small-angle neutron scattering Journal of structural biology · 2019 · 9 citations
    16. Cortical cell types and intermediate filament arrangements correlate with fiber curvature in Japanese human hair Journal of structural biology · 2008 · 62 citations
    17. Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia PLOS ONE · 2012 · 22 citations
    18. Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998 · 46 citations
    19. Disulfide Cross-Linked Network Structure of Intermediate Filament and Matrix in Hair and Wool Cortices Sen'i Gakkaishi · 2015 · 4 citations
    20. 564 Vertex and Occipital Intermediate and Terminal Hair Follicles from Androgenetic Alopecia Patients are Differentially Affected by Testosterone Ex Vivo Journal of Investigative Dermatology · 2022
    21. The Effect of Intermediate Treatment Using Natural Polyphenol Cross-linker on Perming Efficiency and Hair Protection 2021
    22. Mediator1: An Important Intermediary of Vitamin D Receptor–Regulated Epidermal Function and Hair Follicle Biology Journal of Investigative Dermatology · 2012 · 5 citations
    23. Prostaglandin F2α stimulates the growth of human intermediate hair follicles in ex vivo organ culture with potential clinical relevance Frontiers in Physiology · 2025
    24. Single-cell sequencing reveals the intermediate cell state and function of dermal papilla cells in the hair follicle cycle of cashmere goats Research Square (Research Square) · 2020
    25. Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair Journal of The Royal Society Interface · 2017 · 8 citations
    26. ESDR564 – Vertex and Occipital Intermediate and Terminal Hair Follicles from Androgenetic Alopecia Patients are Differentially Affected by Testosterone Ex Vivo 2022
    27. Characterization of a Hair (Wool) Keratin Intermediate Filament Gene Domain Journal of Investigative Dermatology · 1994 · 40 citations
    28. Effect of Aspartic Acid Intermediate Treatment on Virgin Hair by Permanent Wave 2021 · 1 citations
    29. Hair follicle gene expression profiling in the SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS) BMC Medical Genomics · 2025
    30. Supplementary material from "Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair" 2017