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    Glossary Interleukin-6

    protein involved in immune response and inflammation

    Interleukin-6 (IL-6) is a type of protein called a cytokine that plays a crucial role in the body's immune response. It is involved in inflammation and infection responses, as well as the regulation of metabolic, regenerative, and neural processes. Elevated levels of IL-6 are often associated with chronic inflammatory diseases and conditions such as rheumatoid arthritis and alopecia areata.

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    1. Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proceedings of the National Academy of Sciences · 1992 · 221 citations
    2. WNT5A drives interleukin-6-dependent epithelial–mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis Burns & Trauma · 2022 · 56 citations
    3. Testosterone stimulates proliferation and inhibits interleukin‐6 production of normal and hereditary gingival fibromatosis fibroblasts Oral Microbiology and Immunology · 2002 · 39 citations
    4. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages Annals of the Rheumatic Diseases · 2014 · 36 citations
    5. Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2016 · 16 citations
    6. Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps Mediators of inflammation · 2019 · 14 citations
    7. Interleukin 6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration Experimental Dermatology · 2015 · 11 citations
    8. To evaluate the role of interleukin-6 in alopecia areata Journal of the Pakistan Medical Association · 2024 · 5 citations
    9. The role of salivary vitamin D and interleukin-6 on non-scarring Alopecia Archives of Dermatological Research · 2024 · 3 citations
    10. Reduction of Interleukin-6 after PRP-Exosomes Treatment in A Mouse Model of Androgenetic Alopecia 2025
    11. Topische Immuntherapie mit Diphenylcyclopropenon bei verschiedenen Typen der Alpecia areata: Assoziation zu klinischen Parametern und einem funktionellen Genpolymorphismus des Interleukin-6-Promotors Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · 2005
    12. Dermatologic Changes Associated With Interleukin 2 Administration JAMA · 1987 · 123 citations
    13. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    14. The many faces of interleukin-17 in inflammatory skin diseases 2016 · 77 citations
    15. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    16. The association between Interleukin (IL)-4 gene intron 3 VNTR polymorphism and alopecia areata (AA) in Turkish population Gene · 2013 · 42 citations
    17. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997 · 38 citations
    18. Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions Frontiers in Immunology · 2022 · 34 citations
    19. Interleukin-1β-Induced Inhibition of Hair Growth In Vitro Is Mediated by Cyclic AMP Journal of Investigative Dermatology · 1997 · 33 citations
    20. Interleukin-10-deficient Mice Are Less Susceptible to the Induction of Alopecia Areata Journal of Investigative Dermatology · 2002 · 31 citations
    21. Recurrence of Pemphigus Vulgaris Associated With Interleukin 2 Therapy Archives of Dermatology · 1994 · 25 citations
    22. Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans Journal of Interferon & Cytokine Research · 2014 · 22 citations
    23. Alopecia Diffusa while Using Interleukin-17 Inhibitors against Psoriasis Vulgaris Case Reports in Dermatology · 2019 · 20 citations
    24. Minoxidil downregulates Interleukin-1 alpha gene expression in HaCaT cells International Journal of Trichology · 2018 · 16 citations
    25. Evaluation of the level of serum Interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with disease severity in patients with alopecia areata 2021 · 14 citations
    26. Serum level of interleukin-15 in active alopecia areata patients and its relation to age, sex, and disease severity Advances in Dermatology and Allergology · 2020 · 14 citations
    27. Influence of interleukin‐1α on androgen receptor expression and cytokine secretion by cultured human dermal papilla cells Experimental Dermatology · 2006 · 14 citations
    28. Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata Journal of Clinical Laboratory Analysis · 2018 · 12 citations
    29. A functional polymorphism in interleukin-1α (IL1A) gene is associated with risk of alopecia areata in Chinese populations Gene · 2013 · 11 citations
    30. Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice Inflammation and Regeneration · 2023 · 7 citations