52 citations
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October 2007 in “Molecular Therapy” Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.
30 citations
,
January 2023 in “EFSA journal” This review establishes a tolerable upper intake level of 255 μg/day for selenium in adults, warning that supplements and Brazil nuts may cause excess intake.
192 citations
,
January 2018 in “Burns & Trauma” This review discusses the advancements in biologic skin substitutes for wound treatment and their potential in enhancing cutaneous regeneration but reports no new clinical results.
4 citations
,
July 2023 in “Pharmaceutics (Basel)” This study reviews various skin models and methodologies used to assess the follicular penetration of nanoparticle-based drugs, highlighting inconsistencies that complicate comparisons and aims to establish more uniform protocols for clearer study outcomes.
80 citations
,
March 2004 in “Neuropediatrics” This article presents an update on a family with Coats' plus disorder, documenting additional symptoms and two new similar cases, and reviews literature suggesting a link to dyskeratosis congenita for potential molecular insights.
23 citations
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January 2018 in “PLoS ONE” In this study, researchers found that changes in Wnt signaling pathways play a crucial role in feather follicle morphogenesis during chicken embryo development.
January 1981 in “Purdue e-Pubs (Purdue University)” This study observed that the pig integument is similar to human skin in both light and electron microscopy, with minimal postnatal developmental differences noted.
61 citations
,
February 1982 in “Cell and Tissue Research”
1 citations
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February 2004 in “Dermatologic Surgery” This study found that using deep plane fixation during scalp surgeries significantly reduced closure tension and allowed for increased tissue excision compared to standard techniques without fixation.
June 2014 in “Experimental dermatology” This commentary discusses the role of the epidermis in hair follicle induction and reports no new research findings.
February 2004 in “Dermatologic Surgery” This study found that deep plane fixation in scalp surgeries allowed for tension-reduced wound closures and increased tissue excision compared to techniques without deep plane fixation.
12 citations
,
January 1994 in “PubMed” This study found that elastic fibre arrangements in the skin of domesticated mammals vary with hair density, with densely-haired species having horizontal fibres and sparsely-haired ones exhibiting a sponge-like system.
7 citations
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June 2001 in “PubMed” This study details the histological structure of the white domesticated pig's ear skin and discusses its relevance as a model for human dermatological research.
In this study, penetration of FA-PLGA nanoparticles into hair follicles was observed in excised dog, rat, and porcine skin, with the deepest penetration in porcine skin, suggesting its similarity to human skin for drug delivery studies.
October 2022 in “Hair Transplantation” This source emphasizes the importance of understanding scalp anatomy for surgeons performing aesthetic and reconstructive procedures, as such knowledge aids in planning, predicting challenges, and avoiding complications during surgery.
December 2010 in “HAL (Le Centre pour la Communication Scientifique Directe)” This study found that the corneal epithelium differentiation program can proceed independently of lens formation, suggesting the corneal program is the default in eye development.
44 citations
,
May 2008 in “Acta Zoologica” This study explains how the development of keratin-associated proteins in embryonic epidermis is crucial for forming protective barriers in vertebrates, enabling them to adapt to terrestrial environments.
82 citations
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January 2006 in “International review of cytology” Vertebrate skin evolved to be more specialized and complex, especially in land animals.
This chapter emphasizes the critical role of the integumentary system in animal physiology, detailing its structures, immune functions, and sensory capabilities as crucial for homeostasis, protection, and various physiological processes.
38 citations
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July 2004 in “Journal of experimental zoology. Part B, Molecular and developmental evolution” This article discusses a hypothesis on the development and evolution of scales, hairs, and feathers from fish to amniotes, based on regions of dermo-epidermal interactions in skin, but reports no new findings.
73 citations
,
January 2016 in “International review of cell and molecular biology” Cornification evolved from keratinization in vertebrates, with differences between mammals and sauropsids.
73 citations
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June 2017 in “Experimental Dermatology” The authors suggest that tooth, dermal scale, epidermal scale, feather, and hair evolved in parallel from a shared placode/dermal cell unit in an early vertebrate gnathostome with odontodes, around 420 million years ago.
1 citations
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December 2020 The skin is the body's largest organ, with layers, cells, and structures that protect and support it.
62 citations
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October 2013 in “Journal of Human Evolution/Journal of human evolution” This review highlights the significance and future potential of forensic DNA phenotyping for predicting human phenotypes from crime scene DNA but reports no new results.
August 2018 in “Journal of Investigative Dermatology” This study found that humans have a much higher eccrine gland density than chimpanzees and macaques, suggesting a unique evolutionary path for human skin features.
December 2025 in “Toxicologic Pathology” This study outlines the complex structure and various functions of the skin, emphasizing its role as a barrier against external insults, a sensory receptor, and its importance in vitamin D synthesis.
January 2013 in “Journal of Investigative Dermatology” April 2015 in “Journal of Investigative Dermatology” 68 citations
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November 2018 in “Molecular Biology and Evolution” This study found that keratin genes in the epidermis of aquatic mammals like cetaceans have evolved to replace stress-inducible keratins K1 and K10 with constitutively expressed K6 and K17, suggesting adaptations to their environment.