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    Glossary Innate Immunity

    body's first, non-specific defense against pathogens

    Innate immunity, also known as natural or non-specific immunity, is the body's first line of defense against pathogens. It includes physical barriers like skin and mucous membranes, as well as immune cells like macrophages and neutrophils that can quickly respond to a wide range of invaders without prior exposure. This system provides immediate, but generalized, protection and does not adapt or improve with repeated exposure to the same pathogen.

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    1. Innate type 2 immunity controls hair follicle commensalism by Demodex mites Immunity · 2022 · 24 citations
    2. Type 2 innate immunity regulates hair follicle homeostasis to control <i>Demodex</i> pathosymbionts bioRxiv (Cold Spring Harbor Laboratory) · 2021
    3. Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe? Frontiers in Immunology · 2024
    4. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity Nature · 2010 · 717 citations
    5. Extraskeletal actions of vitamin D Annals of the New York Academy of Sciences · 2016 · 119 citations
    6. Dandruff Is a Low‐Grade Inflammatory Condition Featuring Hyperproliferative Keratinocytes, Interleukin‐17‐Producing T Cells, and N‐Acyl Ethanolamines Immunity Inflammation and Disease · 2026
    7. Effect of the multifunctional cosmetic ingredient sphinganine on hair loss in men and women with diffuse hair reduction Clinical, cosmetic and investigational dermatology · 2016 · 3 citations
    8. Significance of stress keratin expression in normal and diseased epithelia iScience · 2024 · 47 citations
    9. Genetic Variants and Protective Immunity against SARS-CoV-2 Genes · 2022 · 5 citations
    10. Alarmin Cytokines as Central Regulators of Cutaneous Immunity Frontiers in Immunology · 2022 · 51 citations
    11. Vitamin D metabolism and function in the skin Molecular and cellular endocrinology · 2011 · 185 citations
    12. An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system 2021 · 6 citations
    13. Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis Nature Communications · 2026
    14. Analyzing the innate immunity of NIH hairless mice and the impact of gut microbial polymorphisms on<i>Listeria monocytogenes</i>infection Oncotarget · 2017 · 6 citations
    15. https://researchopenworld.com/genetics-of-hidradenitis-suppurativa/# 2020
    16. Mechanisms regulating skin immunity and inflammation Nature Reviews Immunology · 2014 · 610 citations
    17. Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms Inflammation Research · 2020 · 82 citations
    18. Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier Trends in immunology · 2017 · 181 citations
    19. Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection International journal of molecular sciences · 2024
    20. Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity Genes and Immunity · 2010 · 20 citations
    21. Beyond acne: Current aspects of sebaceous gland biology and function Reviews in Endocrine and Metabolic Disorders · 2016 · 97 citations
    22. Innate immunity and the regulation and mobilization of keratinocyte stem cells: are the old players playing a new game? Experimental dermatology · 2012 · 11 citations
    23. Trained Immunity and Local Innate Immune Memory in the Lung Cell · 2018 · 77 citations
    24. Androgens and androgen receptor action in skin and hair follicles Molecular and Cellular Endocrinology · 2017 · 100 citations
    25. How to diagnose a lipodystrophy syndrome Annales d'Endocrinologie · 2012 · 53 citations
    26. Adipose stem cells from type 2 diabetic mice exhibit therapeutic potential in wound healing Stem Cell Research & Therapy · 2020 · 21 citations
    27. Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition Stem cell research & therapy · 2023 · 4 citations
    28. TLR2 regulates hair follicle cycle and regeneration via BMP signaling eLife · 2023 · 1 citations
    29. Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense Journal of Investigative Dermatology · 2019 · 49 citations
    30. Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review International Journal of Molecular Sciences · 2022 · 10 citations