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    Glossary Innate Immunity

    body's first, non-specific defense against pathogens

    Innate immunity, also known as natural or non-specific immunity, is the body's first line of defense against pathogens. It includes physical barriers like skin and mucous membranes, as well as immune cells like macrophages and neutrophils that can quickly respond to a wide range of invaders without prior exposure. This system provides immediate, but generalized, protection and does not adapt or improve with repeated exposure to the same pathogen.

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    1. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity Nature · 2010 · 717 citations
    2. The Epidermal Vitamin D System and Innate Immunity: Some More Light Shed on This Unique Photoendocrine System? Dermatology · 2008 · 14 citations
    3. Innate immunity and the regulation and mobilization of keratinocyte stem cells: are the old players playing a new game? Experimental dermatology · 2012 · 11 citations
    4. Analyzing the innate immunity of NIH hairless mice and the impact of gut microbial polymorphisms on<i>Listeria monocytogenes</i>infection Oncotarget · 2017 · 6 citations
    5. Trained Immunity and Local Innate Immune Memory in the Lung Cell · 2018 · 77 citations
    6. Innate type 2 immunity controls hair follicle commensalism by Demodex mites Immunity · 2022 · 24 citations
    7. 498 Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT 2019
    8. Type 2 innate immunity regulates hair follicle homeostasis to control <i>Demodex</i> pathosymbionts bioRxiv (Cold Spring Harbor Laboratory) · 2021
    9. EMATOPOIESIS REVOLVES AROUND THE PRIMORDIALEVOLUTIONAL RHYTHM OF INNATE IMMUNITY AND PURINERGIC SIGNALING – A JOURNEY TO THE DEVELOPMENTAL ROOTS Wiadomości Lekarskie · 2024
    10. Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations Frontiers in immunology · 2022 · 21 citations
    11. Mechanisms regulating skin immunity and inflammation Nature Reviews Immunology · 2014 · 610 citations
    12. Hidradenitis suppurativa: A folliculotropic disease of innate immune barrier dysfunction? Experimental dermatology · 2021 · 9 citations
    13. Clinical Spectrum of Cutaneous, Ocular, and Hair Manifestations in Patients With Inborn Errors of Immunity: Insights From a Single Center in Turkey Immunity Inflammation and Disease · 2026
    14. New developments in our understanding of acne pathogenesis and treatment Experimental dermatology · 2009 · 466 citations
    15. Beyond acne: Current aspects of sebaceous gland biology and function Reviews in Endocrine and Metabolic Disorders · 2016 · 97 citations
    16. Understanding autoimmunity of vitiligo and alopecia areata 2016 · 74 citations
    17. Resident Memory T Cells in Autoimmune Skin Diseases Frontiers in immunology · 2021 · 50 citations
    18. Significance of stress keratin expression in normal and diseased epithelia iScience · 2024 · 47 citations
    19. Alopecia Areata: An Autoimmune Disease of Multiple Players ImmunoTargets and therapy · 2021 · 31 citations
    20. The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier Frontiers in Immunology · 2021 · 23 citations
    21. Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity Genes and Immunity · 2010 · 20 citations
    22. Deciphering the microbiology of hidradenitis suppurativa: a step forward towards understanding an enigmatic inflammatory skin disease Experimental Dermatology · 2015 · 8 citations
    23. Genes and Immune Response in Alopecia Areata: Review of the Alopecia Areata Research Summit First Day Proceedings Journal of Investigative Dermatology Symposium Proceedings · 2013 · 6 citations
    24. Effect of the multifunctional cosmetic ingredient sphinganine on hair loss in men and women with diffuse hair reduction Clinical, cosmetic and investigational dermatology · 2016 · 3 citations
    25. Psoriasis and Related Disorders 2024 · 1 citations
    26. TLR2 regulates hair follicle cycle and regeneration via BMP signaling eLife · 2023 · 1 citations
    27. Joint Public Review: TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling 2023
    28. TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling. bioRxiv (Cold Spring Harbor Laboratory) · 2023
    29. CAQ Corner: Basic concepts of transplant immunology Liver transplantation · 2022
    30. Seborrheic dermatitis and pityriasis sicca: A review Cosmoderma · 2022