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Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Dermoscopy is a useful tool for identifying features of skin conditions, but more research is needed to define its role in dermatology.

BAY 43-9006 helps control kidney cancer growth but doesn't significantly increase overall survival.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Calcium affects where root hairs grow, but other unknown factors determine their growth direction.