May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study revealed that tofacitinib may inhibit CD8+ T cell infiltration in alopecia areata by modulating the linoleic acid metabolism-Mg2+ pathway, providing new insights for potential treatments and diagnosis.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this study, researchers found that circulating exosomes isolated from the plasma of Xinji fine-wool and small-tailed Han sheep influenced hair growth characteristics in mice, altering follicle and hair shaft diameters, and affecting hair follicle development and melanin synthesis.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study investigated the impact of circulating exosomes from Xinji fine-wool and small-tailed Han sheep on hair growth in mice, finding that these exosomes influenced hair follicle development and melanin synthesis, with differences noted in hair follicle and hair diameters between different exosome treatments.
November 2024 in “Image Analysis & Stereology” This study introduced a novel, weakly supervised method for segmenting hair in Scanning Electron Microscope images using simple image-level annotations, achieving over 30% improvement in mean Hausdorff Distance compared to Unet and SAM, while enhancing interpretability and refinement.
January 2024 in “International Journal of Advanced Computer Science and Applications” This review reports that while deep learning shows promise in diagnosing scalp disorders from images, challenges remain with data quality and model interpretability, suggesting that integrating explainable AI techniques is crucial for building trust and facilitating clinical adoption.
December 2023 in “Journal of clinical medicine” This study reports the case of an elderly patient with a keratosis pilaris-like skin eruption after beginning treatment with imatinib for chronic myeloid leukemia, discussing similar skin reactions to BCR-ABL inhibitors and exploring potential mechanisms behind these adverse cutaneous reactions.
This review discusses recent advances in noninvasive hair imaging technologies, such as global photography, trichoscopy, reflectance confocal microscopy, and optical coherence tomography, highlighting their potential to improve hair diagnostics and treatment monitoring, while also outlining their clinical applications and limitations.
This study describes a new method using ImageJ to quantitatively assess hair loss in mice with alopecia areata, offering a more precise and reproducible alternative to traditional visual scoring systems by employing image-based analysis techniques.
April 2023 in “Journal of Investigative Dermatology” A new image-based method improves accuracy in measuring hair loss in mice.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Imaging Mass Cytometry effectively visualizes multiple biomarkers in alopecia areata, enhancing analysis of immune cell and tissue interactions in hair pathology.
January 2022 in “The Pan African medical journal” This article discusses the rare condition of hypertrichosis, highlighting a case of a 10-year-old boy with congenital hair growth and emphasizing the need for patient support due to limited treatment options.
December 2021 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found a significant association between montelukast and neuropsychiatric adverse events such as suicidal ideation and depression, suggesting that the drug's interaction with specific genes may contribute to these effects.
This study found that GPC1 is a key regulator of angiogenesis in hair follicles and may be an interesting target for addressing alopecia in dermatology research.
This study found that GPC1 plays a crucial role in regulating angiogenesis in human dermal microvascular endothelial cells, which may make it a potential target in alopecia treatment research.
January 2017 in “Nihon Keshouhin Gijutsushakaishi/Journal of S C C./Nihon Keshouhin Gijutsushakai kaishi” This study found that hair damage from sunlight and chemical processes like perms and bleaching varies in internal microstructure changes, suggesting that protective techniques should be tailored to the type of chemical treatment used.
305 citations
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June 2012 in “Nature” This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.
56 citations
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June 2015 in “Nature Protocols” This protocol describes using two-photon laser-scanning microscopy to study hair regeneration in live mice, offering detailed imaging capabilities for observing hair follicle stem cell behavior and manipulating cellular populations.
50 citations
,
December 2011 in “Skin Research and Technology” In this study, the researchers reported that their novel algorithm for hair restoration in dermoscopy images achieved high accuracy and texture preservation, outperforming other techniques in diagnostic accuracy and texture quality measures.
42 citations
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January 2011 in “Journal of Biomedical Optics” This study demonstrates that spatially resolved IR and Raman imaging can effectively reveal the molecular structure and composition of untreated human hair, providing insights into its chemistry and structural integrity.
37 citations
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July 2016 in “Current Opinion in Cell Biology” This review summarizes recent discoveries about how tissue-resident stem cells interact with their environments during normal conditions and after injury, without reporting new results.
31 citations
,
August 2001 in “PubMed” This study found that the TrichoScan method detected significant increases in hair counts and cumulative hair thickness in men after finasteride treatment, suggesting its potential for monitoring hair treatment responses.
28 citations
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March 2019 in “Cellular Microbiology” This review discusses the advancements enabled by intravital microscopy in understanding host-parasite interactions in living animals and reports no new clinical results.
23 citations
,
March 2023 in “eLife” This study reveals that epidermal stem cell differentiation in mice involves dynamic transcriptional changes, with Keratin-10 transcription preceding gradual chromatin compaction shifts associated with differentiation.
21 citations
,
November 2018 in “Journal of Psychosomatic Obstetrics & Gynecology” This study found that women with PCOS exhibited higher levels of alexithymia and body uneasiness compared to healthy controls, affecting their psychological and social well-being.
19 citations
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January 2013 in “Frontiers in Neuroanatomy” This study demonstrates a method using intravital imaging to observe sensory hair-cell development and regeneration in zebrafish, which may facilitate assays for drug discovery related to aural function preservation.
19 citations
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July 2009 in “Clinical and Experimental Dermatology” This article discusses how the balding scalp's exposure to UV and near-infrared light may accelerate aging, with changes detectable under ultraviolet light; it presents no new clinical findings.
17 citations
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December 2014 in “Cell Stem Cell” This discussion explores advances in intravital imaging for visualizing stem cells, highlighting key discoveries and potential future developments; it reports no new experimental results.
15 citations
,
February 2003 in “British Journal of Dermatology” This study demonstrated that using morphometric and 3D reconstruction software to evaluate scalp biopsies in non-cicatricial alopecias may be feasible and sensitive for detecting subtle follicular changes.
14 citations
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January 2018 in “Scientific reports” This study demonstrated that bioluminescence imaging of NG2+ cells in transgenic rats allows in vivo monitoring of hair follicle cycles to study hair growth and follicle regeneration.
14 citations
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July 2007 in “International Journal of Cosmetic Science” This study found that a new 3D image analysis method from SEM images enables quick and accurate measurement of cuticle scale heights in hair fibers.