Alteration Of Hair Growth In Mice By Circulating Exosomes From Xinji Fine-Wool And Small-Tailed Han Sheep

This study explored the impact of miRNAs in circulating exosomes from Xinji fine-wool and small-tailed Han sheep on hair growth in mice. Mice injected with exosomes from small-tailed Han sheep (SPE) exhibited significantly larger hair follicle diameters and hair thickness compared to those injected with exosomes from Xinji fine-wool sheep (XPE) and the control group. The expression of hair follicle growth markers and melanin synthesis genes suggested that circulating exosomes can accelerate hair follicle development and affect melanin synthesis. The SPE group showed higher levels of specific miRNAs and a-SMA protein, indicating a more pronounced effect on hair growth.