5 citations,
May 2011 in “European Journal of Medical Genetics” A genetic duplication on chromosome 5 was linked to a woman's unique combination of medical conditions.
1 citations,
February 2023 in “International Journal of Rheumatic Diseases” This case-based review analyzed three instances of tuberculosis (TB) mimicking systemic lupus erythematosus (SLE) flare, with patients aged 27 to 32 years. These cases lacked typical SLE features like butterfly erythema, lupus hair, alopecia, or proteinuria. The study found that TB could induce the production of various autoantibodies, such as anti-nuclear and anti-double-stranded DNA antibodies, which are usually seen in SLE. However, these autoantibodies did not change the clinical or radiographic presentation of TB and were not present after the infection resolved. The resistance of SLE-like symptoms to steroid and immunosuppressive treatments suggested an infectious cause. The findings highlight the importance of considering active TB in patients with SLE-like symptoms, especially when specific serological markers and hypocomplementemia are present.
1 citations,
July 2016 in “Journal of Reproductive Health and Medicine” Diagnosing new systemic lupus during pregnancy is hard but important for the health of the mother and baby.
A woman in Sri Lanka was diagnosed with lupus after presenting with protein loss from the gut and other symptoms.
SLE should be considered in unexplained fevers, even in males.
227 citations,
November 2004 in “Medicine” Older adults diagnosed with lupus show less severe symptoms but have a lower survival rate, often due to age-related factors.
1 citations,
May 2021 in “Annals of the rheumatic diseases” Tofacitinib is a promising treatment for children with rheumatic diseases.
87 citations,
July 2012 in “Expert Review of Clinical Immunology” Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.
63 citations,
December 2002 in “Archives of Dermatology” The 308-nm excimer laser is a promising treatment for vitiligo with varying success and mild side effects.
46 citations,
June 2018 in “American Journal of Clinical Dermatology” Hair loss is common in lupus patients and can be permanent or reversible, depending on the type, with various treatments available.
41 citations,
August 1988 in “Journal of The American Academy of Dermatology” A woman with subacute cutaneous lupus erythematosus had widespread skin symptoms triggered by medication and sunlight, which improved with specific treatments.
12 citations,
April 2018 in “Revista Brasileira de Ginecologia e Obstetrícia” Women with Systemic Lupus Erythematosus should have closely monitored pregnancies and avoid certain medications to improve their pregnancy outcomes.
This study analyzed 89 Mexican children with childhood-onset systemic lupus erythematosus (cSLE), including 23 males and 66 females, to compare clinical and immunologic patterns by gender. Males exhibited higher prevalence of serositis, positive anti-DNA antibodies (88.9% vs. 42.9%), and renal involvement, including granular casts, proteinuria, and lower glomerular filtration rates. Females showed more hair loss. Males had higher average hemoglobin levels (11.47 g/dL vs. 9.84 g/dL) and more frequent use of hydroxychloroquine, cyclophosphamide, and mycophenolate. The study suggests that gender-specific analysis could improve treatment strategies for cSLE.
December 2023 in “Curēus” A woman with lupus had rare severe symptoms but improved with treatment.
Recognizing unusual brain and skin symptoms is crucial for diagnosing lupus early.
May 2023 in “Karnataka Pediatric Journal” An 8-year-old girl was diagnosed with acute pancreatitis and systemic lupus erythematosus (SLE) after presenting with symptoms including abdominal pain, nausea, vomiting, fever, alopecia, oral ulceration, and glossitis. Elevated serum amylase and lipase levels confirmed pancreatitis, while other tests confirmed SLE. Treatment with glucocorticoids and immunosuppressive therapy led to an improvement in her condition. SLE-related pancreatitis is rare but severe in children, with high mortality if untreated. Early diagnosis and aggressive treatment are crucial. The patient is now stable and in remission with regular follow-up.
6 citations,
April 2021 in “Frontiers in Immunology” A patient with lupus and long-term hair loss saw significant hair regrowth after using the drug tofacitinib.