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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

PCOS affects a similar percentage of Black and White women in the Southeastern United States.

Hair growth is cyclic and influenced mainly by local factors.

Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Rosacea is a skin condition with unclear causes, classified into four subtypes.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.

PCOS affects about 4% of women in the southeastern U.S. equally across Black and White populations.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Myrtle has various health benefits and potential for medicine development.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.