17 citations
,
March 2012 in “Journal of biological chemistry/The Journal of biological chemistry” In this study, researchers found that overexpression of the hairless protein in Hr mutant mice disrupts inner root sheath formation by downregulating Dlx3 and associated keratins in hair follicle development.
5 citations
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December 2023 in “Current Biology” A feedback loop between LRH and RSL4 controls root hair growth in Arabidopsis.
January 2002 in “Agritrop (Cirad)” This study found that mutations in exon 3 of the hr gene are strongly associated with congenital hypotrichosis in Valle del Belice sheep, suggesting a potential genetic link to the disorder.
10 citations
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January 1989 in “Archives of Dermatological Research” The method effectively analyzes human hair proteins, especially nonfilamentous ones.
December 2021 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that knocking out the Hars2 gene in mouse cochlear hair cells led to mitochondrial dysfunction and ROS stress, resulting in progressive hearing loss and differential effects on inner and outer hair cells.
September 2017 in “Journal of Investigative Dermatology” This study found that after four weeks of daily use, the roughness of the hair surface significantly decreased, as shown through quantitative image analysis using HIROX.
288 citations
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June 2009 in “Human reproduction update” This review examines various methods for assessing hair growth in women, highlighting the usefulness of the mFG visual scoring method for diagnosing hirsutism despite its limitations.
26 citations
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September 1999 in “Canadian Journal of Botany” This study found that a recessive mutation in the RHD4 gene of Arabidopsis thaliana leads to slower and more variable tip growth in seedling root hairs, resulting in shorter and wider hairs than in wild-type plants.
78 citations
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November 2005 in “Endocrinology” This study found that Hairless (Hr) acts as a corepressor of the vitamin D receptor (VDR) in human keratinocytes, blocking the action of vitamin D on keratinocyte differentiation.
1 citations
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September 2021 in “Biomedical & Pharmacology Journal” This study found that the reticulocyte hemoglobin content (CHr) most frequently indicated iron deficiency in female patients with diffuse non-scarring hair loss.
2 citations
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May 2013 in “The primary care companion for CNS disorders” This case report suggests that long-acting injectable risperidone may induce hirsutism in some patients, and clinicians should monitor for this potential side effect when prescribing this antipsychotic.
1 citations
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July 2007 in “Journal of Investigative Dermatology” The mutation causes hairless mice due to mislocalized and dysfunctional HR protein.
January 2025 in “Journal of Raman Spectroscopy” This study observed that the Raman spectra of human hair cuticle vary with polarization and direction of signal collection, identifying certain spectral bands as markers sensitive to the structural changes in keratin secondary and tertiary structures.
47 citations
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May 1994 in “Experimental Brain Research” This study observed that innervation of the mystacial pad in rats by fine-caliber axons is more extensive and complex than previously described, with distinct differences in labeling patterns depending on the tracer and survival time.
21 citations
,
June 2009 in “Mammalian genome” This study describes a mouse model for Marie Unna Hereditary Hypotrichosis, identifying mutations in the hairless gene that result in sparse or absent hair and cyst-like hair follicles.
June 2025 in “Rapid Communications in Mass Spectrometry” 6 citations
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June 1986 in “The Journal of Dermatology” This report discusses a case of reticular erythematous mucinosis syndrome, highlighting minimal mucin deposition and significant lymphocytic infiltration around the hair follicle, contributing to the ongoing debate about its nature as a mucinosis.
January 2020 in “Przegla̧d dermatologiczny” This article presents a clinical approach to diagnosing and managing hirsutism from a dermatological perspective, but it reports no new clinical findings.
September 1997 in “Journal of the European Academy of Dermatology and Venereology” Hirsute women with ovarian-sourced hirsutism are more likely to have irregular periods, with higher BMI and altered hormone ratios.
1 citations
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March 2020 in “Hair transplant forum international” This study describes new devices, "HairMeasure" and "Scalp Zone Identifier," which offer an economical method to calculate Hair Mass Index without disposable materials.
3 citations
,
December 1982 in “Australasian journal of dermatology” This article reviews approaches to managing hirsutism but does not report new clinical findings.
15 citations
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May 2017 in “Journal of Cellular Biochemistry” This review discusses the role of the hairless protein (HR) in alopecia and cancer, noting its potential importance in cancer cell growth and survival, and reports no new experimental results.
18 citations
,
October 2009 in “Endocrinology” This study demonstrated that both HR isoforms are expressed in keratinocytes, but HRDelta1072-1126 lacks corepressor activity and may act as a coactivator by inhibiting HDAC recruitment to the VDR transcriptional complex.
26 citations
,
December 1999 in “Journal of the American Academy of Dermatology” This study found that normal-mode ruby laser treatment significantly improved facial hirsutism and maintained results for at least 48 weeks, with repeated treatments enhancing clinical effects.
January 2026 in “International Society of Hair Restoration Surgery” This report highlights that the ISHRS website achieved 1,000,000 active users in 2025, signaling its emergence as a leading global resource for hair restoration information.
4 citations
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October 2007 in “PubMed” This study found that the PQ-70 shampoo formulation demonstrated the highest Hair Humidity Resistance Factor, indicating superior anti-frizz performance compared to other tested shampoos.
July 2010 in “Hair transplant forum international” This article discusses the first international certification examination by the American Board of Hair Restoration Surgery, with no new research findings reported.
December 2022 in “Archives of Clinical Trials” In this case series study, mild ovarian hyperstimulation syndrome was reported in only one out of 118 PCOS patients receiving highly purified HMG injections for IVF treatment.
37 citations
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August 2011 in “Journal of Bone and Mineral Research” This study reported a case of hereditary vitamin D–resistant rickets caused by a single heterozygous missense mutation in the VDR gene, showing dominant-negative effects and reduced response to 1,25-dihydroxyvitamin D3.
April 2026 in “Journal of Cutaneous Pathology” This case report describes the first known instance of alopecia associated with multicentric reticulohistiocytosis, evidenced by scalp biopsy findings of histiocyte infiltration in a 52-year-old woman.