Multicentric Reticulohistiocytosis Induced Alopecia: A Clinical Case Report
April 2026
in “
Journal of Cutaneous Pathology
”
New to Folic acid? There is a guide in the encyclopedia. Read the guide → Studysummary This case report describes the first known instance of alopecia associated with multicentric reticulohistiocytosis, evidenced by scalp biopsy findings of histiocyte infiltration in a 52-year-old woman.
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This case report describes a 52-year-old female diagnosed with multicentric reticulohistiocytosis (MRH), a systemic inflammatory disease characterized by dermatologic and musculoskeletal symptoms. The patient presented with red-brown papules, finger swelling, and muscle pain. A biopsy confirmed MRH, and treatment included prednisone, methotrexate, folic acid, and adalimumab. Subsequently, the patient experienced progressive hair loss on the frontal scalp, with a biopsy revealing a marked decrease in follicular units and histiocyte infiltration. This led to a diagnosis of alopecia secondary to MRH, marking the first reported case of such a condition in the literature.
