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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Testing basal 17-HP levels is a good way to screen for nonclassic adrenal hyperplasia in women with high androgen levels.

Sorafenib is effective in treating Desmoid Tumor/Deep Fibromatosis.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

About 7% to 15% of Iranian women have polycystic ovary syndrome, depending on the criteria used to diagnose it.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

Different types of skin cells play specific roles in development, healing, and cancer.

Keratins are crucial for cell structure, growth, and disease risk.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Noggin is necessary to start the hair growth phase in skin after birth.

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

Androgens can both increase and decrease hair growth in different parts of the body.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

PGD2 stops hair growth and is higher in bald men with AGA.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Stem cell niches are crucial for regulating stem cell renewal and differentiation, and understanding them can help in developing regenerative therapies.

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Lactate production is important for activating hair growth stem cells.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.