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    Glossary Half Maximal Effective Concentration

    concentration needed for 50% of maximum drug effect

    The Half Maximal Effective Concentration, often abbreviated as EC50, is a measure used in pharmacology to indicate the concentration of a drug or substance required to achieve half of its maximum effect. This value helps researchers understand the potency of a compound, with a lower EC50 indicating a more potent substance.

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    1. Anti-Zika Activity of a Library of Synthetic Carbohydrate Receptors Journal of Medicinal Chemistry · 2019 · 11 citations
    2. Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system DOAJ (DOAJ: Directory of Open Access Journals) · 2016 · 2 citations
    3. Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system Research and reports in urology · 2016 · 3 citations
    4. A Retrospective Comparative Study of Two Concentrations of Intralesional Triamcinolone Acetonide in the Treatment of Patchy Alopecia Areata on the Scalp Clinical Cosmetic and Investigational Dermatology · 2020 · 6 citations
    5. An Interventional, Comparative, Prospective Study to Determine Optimum Concentration of Intralesional Triamcinolone Acetonide in Treatment of Alopecia Areata Indian Dermatology Online Journal · 2025
    6. Systematic Review—The Potential Implications of Different Platelet-Rich Plasma (PRP) Concentrations in Regenerative Medicine for Tissue Repair International Journal of Molecular Sciences · 2020 · 115 citations
    7. Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness Molecules · 2020 · 37 citations
    8. Absorption sites of orally administered drugs in the small intestine Expert Opinion on Drug Discovery · 2017 · 55 citations
    9. Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial Journal of The European Academy of Dermatology and Venereology · 2021 · 11 citations
    10. Effectiveness of Autologous Platelet-Rich Plasma for Androgenetic Alopecia: A Double-Center, Non-Controlled, Randomized Clinical Study in Vietnam Clinical Cosmetic and Investigational Dermatology · 2025
    11. Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications Journal der Deutschen Dermatologischen Gesellschaft · 2010 · 19 citations
    12. Investigation on antimicrobial, antioxidant, and anti-cancerous activity of Agaricus bisporus derived β-Glucan against cervical cancer cell line Cellular and molecular biology · 2022 · 2 citations
    13. Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands 2013 · 25 citations
    14. Development of Stratum Corneum Lipid Liposomes for Topical Drug Delivery International Journal of Drug Delivery Technology · 2026
    15. Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus In Vitro and In Vivo Viruses · 2022 · 34 citations
    16. Biomarkers of selenium status in dogs BMC veterinary research · 2016 · 11 citations
    17. Baicalin inhibits recruitment of GATA1 to the HSD3B2 promoter and reverses hyperandrogenism of PCOS Journal of Endocrinology · 2019 · 12 citations
    18. In vitro and in vivo study of dye diffusion into the human skin and hair follicles Journal of biomedical optics · 2002 · 69 citations
    19. Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications Advanced Science · 2023 · 10 citations
    20. Methyl Jasmonate Activates the 2C Methyl-D-erithrytol 2,4-cyclodiphosphate Synthase Gene and Stimulates Tanshinone Accumulation in Salvia miltiorrhiza Solid Callus Cultures Molecules · 2022 · 6 citations
    21. Herbal Shampoo Formulations Enriched with Phytoconstituents as Effective Alternatives to Ketoconazole: Comparative Physicochemical and Antifungal Evaluation Against Malassezia furfur International Journal of Drug Delivery Technology · 2026
    22. Developmental Toxicity of Levo-Alpha-Acetylmethadol (LAAM) in Tolerant Rats International journal of toxicology · 2002 · 4 citations
    23. Moving Beyond Boundaries: Utilization of Longitudinal Exposure–Response Model for Bounded Outcome Score to Inform Decision Making in the Accelerated Drug Development Paradigm Clinical Pharmacokinetics · 2024 · 5 citations
    24. Dutasteride: A Review of its Use in the Management of Prostate Disorders Clinical medicine insights · 2011 · 2 citations
    25. Chitosan stimulates root hair callose deposition and inhibits root hair growth bioRxiv (Cold Spring Harbor Laboratory) · 2023
    26. Targeted transfollicular delivery of artocarpin extract from Artocarpus incisus by means of microparticles European Journal of Pharmaceutics and Biopharmaceutics · 2007 · 24 citations
    27. Pre-clinical non-viral vectors exploited for<i>in vivo</i>CRISPR/Cas9 gene editing: an overview Biomaterials Science · 2022 · 23 citations
    28. Rapid Intravenous Administration of Corticotropin as a Test of Adrenocortical Insufficiency JAMA · 1967 · 17 citations
    29. Immunomodulators in the treatment of cutaneous lymphoma Journal of the European Academy of Dermatology and Venereology · 1999 · 11 citations
    30. Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine 2020 · 3 citations