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    Glossary Keratin Intermediate Filaments

    structural proteins in cells providing support and resilience

    Keratin Intermediate Filaments (KIFs) are structural proteins found in epithelial cells, including those in the skin, hair, and nails. They provide mechanical support and resilience, helping cells withstand stress and maintain their shape. KIFs are a type of intermediate filament, which are part of the cytoskeleton, a network that supports cell structure and function.

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    1. The role of disulfide bond formation in the structural transition observed in the intermediate filaments of developing hair Journal of Structural Biology · 2012 · 39 citations
    2. Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998 · 46 citations
    3. Isolation of intermediate filament assemblies from human hair follicles. The Journal of Cell Biology · 1985 · 28 citations
    4. Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation Journal of Structural Biology · 2006 · 19 citations
    5. Trichohyalin, an intermediate filament-associated protein of the hair follicle. 1986 · 116 citations
    6. In vivo formation steps of the hard α-keratin intermediate filament along a hair follicle: Evidence for structural polymorphism Journal of Structural Biology · 2006 · 22 citations
    7. Complete sequence of a hair-like intermediate filament type II keratin gene DNA sequence · 1993 · 15 citations
    8. Regulation of a hair follicle keratin intermediate filament gene promoter Journal of Cell Science · 1998 · 39 citations
    9. Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene. The EMBO Journal · 1990 · 93 citations
    10. Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family Development · 1992 · 65 citations
    11. Structure of intermediate filament assembly in hair deduced from hydration studies using small-angle neutron scattering Journal of structural biology · 2019 · 9 citations
    12. Carbon-13 n.m.r. studies of keratin intermediate filament of human hair Polymer · 1998 · 5 citations
    13. Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair Journal of The Royal Society Interface · 2017 · 8 citations
    14. Supplementary material from "Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair" 2017
    15. Cortical cell types and intermediate filament arrangements correlate with fiber curvature in Japanese human hair Journal of structural biology · 2008 · 62 citations
    16. pH Dependence of the Coiled-Coil Structure of Keratin Intermediate Filament in Human Hair by 13C NMR Spectroscopy and the Mechanism of Its Disruption Polymer journal · 1998 · 7 citations
    17. Disulfide Cross-Linked Network Structure of Intermediate Filament and Matrix in Hair and Wool Cortices Sen'i Gakkaishi · 2015 · 4 citations
    18. Structural Transition of Trichocyte Keratin Intermediate Filaments During Development in the Hair Follicle 2017 · 7 citations
    19. Characterization of a Hair (Wool) Keratin Intermediate Filament Gene Domain Journal of Investigative Dermatology · 1994 · 40 citations
    20. Role of human type II hair keratins in intermediate filament bundling in vitro 2015
    21. A Unique Type I Keratin Intermediate Filament Gene Family is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles Journal of Investigative Dermatology · 2001 · 41 citations
    22. BMP4 and nuclear laminC orchestrate a expression of AHF/Trichohyalin molecule, a key modulator of keratin intermediate filaments in the hair follicle 2007
    23. The expanding significance of keratin intermediate filaments in normal and diseased epithelia Current opinion in cell biology · 2012 · 186 citations
    24. Cryo-Electron Microscopy of Trichocyte (Hard α-Keratin) Intermediate Filaments Reveals a Low-Density Core Journal of Structural Biology · 2002 · 48 citations
    25. Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament Genomics · 2007 · 27 citations
    26. Structural Hierarchy of Trichocyte Keratin Intermediate Filaments Advances in experimental medicine and biology · 2018 · 15 citations
    27. Annotation of sheep keratin intermediate filament genes and their patterns of expression Experimental Dermatology · 2011 · 83 citations
    28. In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments 2000 · 91 citations
    29. The Autoimmune Regulator (AIRE), Which Is Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17 ˜The œAmerican journal of pathology · 2011 · 24 citations
    30. The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein 1993 · 2 citations