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    Glossary Hair Follicle Tumors

    abnormal growths originating in hair-producing skin structures

    Hair follicle tumors are abnormal growths that originate in the hair follicles, the tiny structures in the skin from which hair grows. These tumors can be benign (non-cancerous) or malignant (cancerous) and may present as lumps or lesions on the skin. They can vary in appearance and behavior, requiring different diagnostic and treatment approaches depending on their type and severity.

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    1. Molecular pathways involved in hair follicle tumor formation: all about mammalian target of rapamycin? Experimental Dermatology · 2009 · 18 citations
    2. Keratinic amyloid deposition in canine hair follicle tumors Veterinary pathology · 2022 · 1 citations
    3. Hair follicle tumors in dogs: A report of two cases Indian Journal of Veterinary Pathology · 2015 · 1 citations
    4. Cylindroma as Tumor of Hair Follicle Origin Journal of Investigative Dermatology · 2006 · 57 citations
    5. Desmoplastic Trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors Curēus · 2020 · 5 citations
    6. Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle UHOD : Uluslararası hematoloji - onkoloji dergisi · 2011 · 1 citations
    7. CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice Cancer Research · 2007 · 141 citations
    8. Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle Science · 2026
    9. Faculty Opinions recommendation of The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2008
    10. Evaluation of hair follicles as a surrogate tissue for pharmacodynamics response in xenograft tumors 2012
    11. Hair Follicle–Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin Cancer Research · 2005 · 76 citations
    12. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma Experimental Dermatology · 2016 · 8 citations
    13. Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch Biochemical and Biophysical Research Communications · 2014 · 8 citations
    14. Skin stem cells and tumor growth : functions of collagen XVIII in hair follicle cycling and skin cancer, and Bmx tyrosine kinase in tumor angiogenesis 2014 · 3 citations
    15. Involvement of hair follicles in skin tumorigenesis, skin homeostasis and wound healing Medical Research Archives · 2025
    16. Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells eScholarship (California Digital Library) · 2018
    17. Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion Cancer research · 2012
    18. Immune Microenvironment of Hair Follicles in Tumor Immunotherapy ImmunoTargets and Therapy · 2026
    19. Seborrheic karatosis, a tumor of the infundibular and isthmus of hair follicles: Identification of hair sheath keratins and histopathological features suggesting hair follicle origin. The Nishinihon Journal of Dermatology · 1989 · 2 citations
    20. The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008 · 127 citations
    21. 17b-Estradiol is Abundant in Skin and Regulates the Hair Follicle Cycle and Mirex Tumor Promotion NCSU Libraries Repository (North Carolina State University Libraries) · 2002
    22. Immunohistochemical Study of Calretinin in Normal Hair Follicles and Tumors With Follicular Differentiation Actas Dermo-Sifiliográficas · 2008 · 15 citations
    23. Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation Journal of cutaneous pathology · 2019 · 4 citations
    24. Hair follicle stem cells: Their location, role in hair cycle, and involvement in skin tumor formation 1993 · 85 citations
    25. Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis Oncogene · 2012 · 52 citations
    26. Differential diagnosis of basal cell carcinoma and benign tumors of cutaneous appendages originating from hair follicles by using CD34. PubMed · 2010 · 13 citations
    27. Relative Amounts of Keratin 17 Are Higher Than Those of Keratin 16 in Hair-Follicle-Derived Tumors in Comparison with Nonfollicular Epithelial Skin Tumors Journal of Investigative Dermatology · 1995 · 31 citations
    28. Hair follicle regeneration suppresses Ras-driven oncogenic growth Journal of Cell Biology · 2019 · 17 citations
    29. Microinjury-Induced Tumor Necrosis Factor-α Surge Stimulates Hair Regeneration in Mice Skin Pharmacology and Physiology · 2023
    30. Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours Development · 2002 · 297 citations