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    Glossary Hair Follicle Stem Cell Differentiation

    process where stem cells become specialized hair cells

    Hair follicle stem cell differentiation is the process by which stem cells in the hair follicle develop into specialized cells that form the various structures of the hair, such as the hair shaft and the surrounding skin. This process is crucial for hair growth and regeneration, as it allows the hair follicle to produce new hair after shedding or damage.

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    1. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    2. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia Molecular and Cellular Endocrinology · 2016 · 47 citations
    3. Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis Frontiers in Cell and Developmental Biology · 2021 · 4 citations
    4. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    5. In vitro neural differentiation of CD34 + stem cell populations in hair follicles by three different neural induction protocols In vitro cellular & developmental biology. Animal · 2014 · 18 citations
    6. In vitro Differentiation of Hair Follicle Stem Cell into Keratinocyte by Simvastatin Iranian Biomedical Journal · 2019 · 10 citations
    7. MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation Human Gene Therapy · 2022 · 2 citations
    8. Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation Cell Death Discovery · 2022 · 1 citations
    9. miR-133a-3p and miR-145-5p co-promote goat hair follicle stem cell differentiation by regulating NANOG and SOX9 expression Animal Bioscience · 2023
    10. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB Molecular Medicine Reports · 2013 · 19 citations
    11. FGF22 Secreted by Hair Papilla Cells Regulates Hair Follicle Stem Cell Proliferation and Differentiation Biomolecules · 2025
    12. miR‑339‑5p negatively regulates loureirin A‑induced hair follicle stem cell differentiation by targeting DLX5 Molecular Medicine Reports · 2018 · 19 citations
    13. Glypican-1, -4 and 6 Participate in the Hair Follicle Stem Cell Differentiation via Specific Interactions with BMP2R, Fz7 and Patched 1 SPIRE - Sciences Po Institutional REpository · 2024
    14. Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation International journal of biological sciences · 2019 · 71 citations
    15. Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777] European Journal of Cell Biology · 2012 · 1 citations
    16. 881 Ionizing radiation triggers dedifferentiation of outer root sheath cells into stem cell-like progenitors for hair follicle regeneration Journal of Investigative Dermatology · 2017
    17. Self-assembled tetrahedral framework nucleic acids promote hair follicle stem cell proliferation and lineage differentiation Chinese Chemical Letters · 2026
    18. Multi-potentiality of a new immortalized epithelial stem cell line derived from human hair follicles In vitro cellular & developmental biology. Animal · 2008 · 34 citations
    19. Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation Stem cells · 2017 · 13 citations
    20. Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS Scientific reports · 2019 · 9 citations
    21. DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages Stem cell research & therapy · 2020 · 8 citations
    22. Exploring the Differentiation Abilities of Hair Follicle and Dental Pulp Stem Cells Into Islet Like Cells Cell Biology International · 2025 · 1 citations
    23. Spatiotemporal immunomodulation by engineered hair follicle stem cell-derived nanovesicles enables scarless regeneration of infected wounds Chemical Engineering Journal · 2026
    24. <i>N</i>1-acetylspermidine is a determinant of hair follicle stem cell fate Journal of Cell Science · 2021 · 17 citations
    25. Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging Frontiers in Aging · 2023 · 3 citations
    26. Coordinating Stem Cell Behavior in the Hair Follicle Digital Commons - RU (Rockefeller University) · 2025
    27. An induced pluripotent stem cell-based approach for hair follicle development and regeneration Regenerative Therapy · 2024
    28. Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma Clinical and Experimental Dermatology · 2019 · 45 citations
    29. Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells Stem Cell Research · 2011 · 73 citations
    30. EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression Aging · 2020 · 12 citations