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Uncombable hair syndrome causes frizzy hair and can affect the nervous system, eyes, and ears, often co-occurring with other hair, skin, nail, and teeth conditions, and is linked to three specific gene mutations.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Young adults have about 230,000 tactile nerve fibers, decreasing 5-8% per decade with age.

Hair follicles in mutant mice self-organize into ordered patterns within a week.

sPLA2-IIE is crucial for normal hair follicle structure and skin health.

The skin has about 230,000 touch-sensitive nerve fibers, with high concentrations in the hands and face.

Different hair follicles in the skin are innervated by unique combinations of mechanosensory neurons, crucial for touch sensation.

Effective management of children's hair loss involves accurate diagnosis, various treatments, and supportive care.

The document reviews various hair and nail disorders, their causes, and treatments, emphasizing the need for proper diagnosis and the link between nail changes and systemic diseases.

Terbinafine can cause hair loss.

Early treatment of children's hair loss, which can be caused by various factors, is important due to its emotional impact.

Cyclosporin doesn't stop hair loss.

Sebum production varies by individual and is influenced by age, gender, and hormones, affecting skin and hair health.

Finasteride can treat hair loss, but may have side effects; evaluate and inform patients of risks.

Botulinum toxin shows promise for various skin conditions but requires more research for confirmation and standardized use.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

Good nutrition is crucial for health and preventing disease, and supplements can help prevent nutrient deficiencies.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Most children with CNS tumors on targeted therapy had skin reactions, which were generally treatable without stopping the therapy.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Covers common skin issues in kids, their diagnosis, treatment, and need for specialist care.

Metformin improved menstrual cycle regularity and signs of hyperandrogenism in adolescent girls with type 1 diabetes but did not improve blood sugar control.

Rosacea is a skin condition with unclear causes, classified into four subtypes.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Silver can help prevent and treat infections but its effectiveness varies and should be weighed against costs and side effects.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Early treatment of acne is crucial to prevent scarring and psychological effects.

Sweat hypersensitivity can cause severe skin issues in horses.

Research on the human skin microbiome has grown, focusing on skin health and diseases, with more studies needed on antibiotic resistance and AI applications.

Hair restoration surgery can have complications; success depends on patient education, careful planning, and proper execution.