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Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

Different types of stem cells help maintain and heal skin.

Human sweat glands have a type of stem cell that can grow well and turn into different cell types.

FoxN1 gene is crucial for proper thymus structure and normal skin appearance.

A specific ATR gene mutation is linked to a hereditary oropharyngeal cancer syndrome.

Genomic profiling for myeloid cancers can find important inherited mutations, but it's challenging when these mutations aren't related to the patient's symptoms.

Three genes linked to the development of trichilemmal cysts were found.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.

Longer GGN repeats in the androgen receptor gene are linked to polycystic ovary syndrome.

A mutation in the HR gene causes a rare form of irreversible hair loss in two Kashmiri families. Whole exome sequencing is effective for finding such mutations.

A new genetic change in the DSC3 gene is linked to a rare condition causing hair loss and skin blisters in a child.

Some Greek melanoma patients have gene mutations linked to increased cancer risk, a new color feature helps diagnose melanoma, the incidence of a skin condition in the Netherlands is rare, and a gene possibly affects male-pattern baldness.

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

Mice without the Sp6 gene have problems developing several body parts, including hair, teeth, limbs, and lungs.

FoxN1 gene is essential for proper thymus structure and preventing hair loss.

The gene Msx2 is crucial for hair follicle regeneration during wound healing.

A gene called Gk5 controls lipid production in the skin and affects hair growth.

A gene deletion in mice causes weak protein, immune issues, hair loss, airway problems, and wasting disease.

The S250C variant in a gene may cause autoimmunity and immunodeficiency by impairing protein function.

The research linked PLCD1 gene variants to the development of trichilemmal cysts.

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

Mutations in the HEPHL1 gene cause abnormal hair and cognitive issues.

Three new types of a skin blistering disease were found, caused by specific gene mutations.

Mutations in the RBPJ gene cause Adams-Oliver Syndrome.

Non-classic congenital adrenal hyperplasia (NCCAH) can mimic PCOS and requires genetic testing for proper diagnosis and treatment.

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

CDP is crucial for lung and hair follicle cell development.

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

The transgene likely activated an oncogene or interrupted a tumor suppressor gene, causing melanoma in mice.