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    Glossary GABAA Receptors

    ion channels in the brain that reduce neuronal excitability

    GABAA receptors, also known as Gamma-Aminobutyric Acid Type A receptors, are a class of receptors in the brain that respond to the neurotransmitter GABA, the primary inhibitory neurotransmitter in the central nervous system. These receptors are ion channels that, when activated, allow chloride ions to enter the neuron, making it less likely to fire and thus reducing neuronal excitability. This mechanism is crucial for regulating brain activity and is a target for various medications, including sedatives, anxiolytics, and anticonvulsants.

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    Research 30 of 544

    1. PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields Brain research · 2017 · 14 citations
    2. Ovarian Cycle‐Related Neurosteroid Regulation of GABA‐A Receptor Subunit Plasticity in the Hippocampus Subfields The FASEB Journal · 2011 · 1 citations
    3. Effect of Neurosteroid Withdrawal on Hippocampal GABA‐A Receptor α4‐Subunit Expression in Female Mice The FASEB Journal · 2008
    4. Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain Journal of neuroscience research · 2017 · 12 citations
    5. Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor Neurobiology of Stress · 2019 · 40 citations
    6. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015 · 33 citations
    7. Changes in expression of the δ subunit of the GABA<sub>A</sub>receptor and in receptor function induced by progesterone exposure and withdrawal Journal of Neurochemistry · 2006 · 25 citations
    8. Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation Psychoneuroendocrinology · 2019 · 12 citations
    9. Aqueous extract of Asiasari radix inhibits formalin-induced hyperalgesia via NMDA receptors Journal of Ethnopharmacology · 2009 · 17 citations
    10. Joint Public Review: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2 2024
    11. Social isolation alters GABAA receptors plasticity and function: effect of voluntary consumption of ethanol Annals of General Psychiatry · 2008
    12. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA<sub>A</sub>Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002 · 269 citations
    13. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations
    14. Neurosteroid Synthesis-Mediated Regulation of GABA<sub>A</sub>Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007 · 238 citations
    15. Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA<sub>A</sub>Miniature IPSCs in Lamina II of the Spinal Cord Journal of Neuroscience · 2004 · 88 citations
    16. Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen–glucose deprivation European Journal of Neuroscience · 2006 · 83 citations
    17. GABAergic neurosteroids mediate the effects of ethanol on long‐term potentiation in rat hippocampal slices European Journal of Neuroscience · 2007 · 48 citations
    18. Enhanced remyelination during late pregnancy: involvement of the GABAergic system Scientific Reports · 2019 · 30 citations
    19. Relating neurosteroid modulation of inhibitory neurotransmission to behaviour Journal of Neuroendocrinology · 2021 · 18 citations
    20. Inhibitory respiratory responses to progesterone and allopregnanolone in newborn rats chronically treated with caffeine The Journal of Physiology · 2015 · 17 citations
    21. Local Changes in Neurosteroid Levels in the Substantia Nigra Reticulata and the Ventral Tegmental Area Alter Chronic Ethanol Withdrawal Severity in Male Withdrawal Seizure‐Prone Mice Alcoholism Clinical and Experimental Research · 2012 · 11 citations
    22. Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice Behavioural Pharmacology · 2017 · 7 citations
    23. Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model Scientific reports · 2019 · 6 citations
    24. Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System Androgens · 2021 · 1 citations
    25. Neurosteroids as Endogenous Regulators of Seizure Susceptibility 2002
    26. Social isolation‐induced increase in α<sub>4</sub>and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA<sub>A</sub>receptor function Journal of Neurochemistry · 2006 · 60 citations
    27. Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids Endocrine, metabolic & immune disorders. Drug targets · 2006 · 26 citations
    28. Unraveling the Complex: Changes in Secondary Science Preservice Teachers' Assessment Expertise ProQuest LLC eBooks · 2012
    29. Neuroactive Steroids: Functions, Mechanisms of Action and Physiologic Relevance Journal of Neurochemistry · 2003
    30. Neurosteroids, neuroactive steroids, and symptoms of affective disorders Pharmacology, Biochemistry and Behavior · 2006 · 82 citations