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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Fat cells help recruit healing cells and build skin structure during wound healing.

The Rotterdam Study aims to understand various diseases in older adults.

Diagnosing PCOS in teenagers is challenging and should use strict criteria to avoid misdiagnosis and unnecessary worry.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Oestrogens are key for bone growth during puberty in both boys and girls.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Stem cell niches support, regulate, and coordinate stem cell functions.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.

Hair follicles may soon be used more for targeted and systemic drug delivery.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Silver nanoparticles coated with substances like PEG showed strong antibacterial effects and improved wound healing when used in hydrogels.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Fat cells in the skin help start healing and form important repair cells after injury.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Children, especially teenagers, can get severe SARS-CoV infection with symptoms similar to adults, but they typically recover well with supportive care.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Understanding the mouse hair cycle is crucial for cancer research.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.