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Repurposing existing drugs for COVID-19 shows promise but requires more research to confirm effectiveness.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

The document concludes that computational methods using networks and various data can improve the process of finding new uses for existing drugs.

Bendamustine, often combined with other drugs, is effective and less toxic for certain blood cancers, but less effective for young, fit patients with CLL.

A machine learning model called CATNIP can predict new uses for existing drugs, like using antidepressants for Parkinson's disease and a thyroid cancer drug for diabetes.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

Low-dose finasteride may cause lasting sexual dysfunction and suicidal thoughts in young men.

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.

Some men experience persistent sexual, neurological, and psychological symptoms after stopping finasteride, but evidence of permanent damage is inconclusive.

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

Doctors should diagnose hair loss by examining the patient and possibly doing tests, and then treat it based on the type, which may prevent permanent hair loss.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

Clinicians should use social and prescription data to track trends in performance-enhancing drug use.

A new, efficient method has been developed to detect darolutamide and thalidomide, drugs used for certain hair loss and prostate cancer treatments, in pharmaceuticals and body fluids.

Low-dose oral minoxidil may help treat hair loss but is not FDA-approved and can cause side effects like unwanted hair growth and heart issues.

The review suggests doctors should carefully weigh risks and benefits of off-label drug use, involve patients in decisions, and calls for better regulations and monitoring.

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

Herbal alternatives like saw palmetto and green tea may offer safe, effective treatment for hormonal hair loss.

Researchers identified five new potential targets for leishmaniasis treatment, suggesting repurposing existing drugs could be effective.

Botulinum toxin may help hair loss by increasing blood flow and reducing harmful factors.

Fluconazole might be a new treatment for a type of diabetes that affects water balance in the body.

Exosomes from hair papilla cells and the Chinese medicine Liao Tuo Fang can potentially promote hair growth and could be used to develop hair growth drugs.

Finasteride and dutasteride effectively treat hair loss, but may cause side effects like sexual dysfunction and depression.

Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Hair follicle culture helps develop new treatments for hair loss.

Quick, selective detection of tadalafil and finasteride in human plasma developed.

The document concludes that doctors should carefully consider off-label drug use in dermatology and always inform patients, while more research is needed on the safety and effectiveness of such practices.

Finasteride and tamsulosin hydrochloride can be safely taken together without significant interaction.