May 2024 in “International Seven Journal of Multidisciplinary” This review discusses fibrosing frontal alopecia, including its causes, mechanisms, and treatments, and emphasizes the need for further research to improve understanding and treatments; it reports no new clinical results.
January 2021 in “Anais do Congresso Brasileiro de Reumatologia 2020” In this case report, tofacitinib led to significant improvement in arthritis and partial improvement in alopecia for a female patient with systemic lupus erythematosus, with no observed adverse effects.
April 2020 in “International journal of research in dermatology” This case report presents an 8-year-old girl with congenital atrichia, marked by complete hair loss and papular lesions, linked to mutations in the human hairless gene.
March 2018 in “Dermatología Argentina” This study found that postmenopausal women in Argentina with frontal fibrosing alopecia had a higher average age of diagnosis than previously reported, with similar clinical features to international cases.
November 2024 in “SKIN The Journal of Cutaneous Medicine” This study found that ritlecitinib, taken daily, led to scalp, eyebrow, and eyelash hair regrowth in patients aged 12 and older with severe and very severe alopecia areata over a 24-month period.
13 citations
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November 2012 in “Journal of The European Academy of Dermatology and Venereology” This study found that topical clobetasol propionate cream provided a modest improvement in hair regrowth for alopecia areata patients, though those with atopy had higher relapse rates after treatment completion.
2 citations
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January 2023 in “Curēus” In this study, low-dose naltrexone significantly reduced erythema in patients with frontal fibrosing alopecia and lichen planopilaris after one year, but no significant improvements were seen in other symptoms.
47 citations
,
June 2014 in “Journal of Dermatological Treatment” This retrospective review found that while intralesional corticosteroids provided symptomatic improvement for lichen planopilaris, hydroxychloroquine with topical corticosteroids led to higher remission rates but did not result in visible hair regrowth.
339 citations
,
February 2014 in “Journal of The American Academy of Dermatology” This study found that eyelash loss, facial papules, and body hair involvement were linked to severe frontal fibrosing alopecia, and antiandrogens were the most effective treatment.
218 citations
,
April 2012 in “British Journal of Dermatology” This updated guideline from the British Association of Dermatologists discusses current recommendations for managing alopecia areata but reports no new clinical research findings.
155 citations
,
September 2008 in “British journal of dermatology/British journal of dermatology, Supplement” This study observed that frontal fibrosing alopecia predominantly affects postmenopausal women, can be associated with lichen planus, and may lead to progressive hairline recession, though this progression is not consistent in all cases.
128 citations
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February 2016 in “British Journal of Dermatology” This study found that patients with alopecia areata experience significant impairments in health-related quality of life, notably affecting mental health, according to various quality of life assessment tools.
117 citations
,
August 2019 in “Drug Design Development and Therapy” This review article provides an updated overview of the pharmacology, mechanism of action, clinical efficacy, and adverse events associated with topical minoxidil, a widely used treatment for androgenetic alopecia and other hair loss conditions, while noting that its exact mechanism is still not fully understood.
64 citations
,
June 2009 in “Journal of The American Academy of Dermatology” This article discusses frontal fibrosing alopecia, noting potential connections to lichen planopilaris, but reports no new clinical findings.
51 citations
,
June 2016 in “Journal of the European Academy of Dermatology and Venereology” In this study, tofacitinib treatment was associated with significant hair regrowth in two patients with alopecia universalis over eight months, with minimal adverse effects reported.
36 citations
,
January 2012 in “International Journal of Trichology” This review discusses madarosis, its diverse causes, and suggests follicular unit transplantation as a useful treatment for scarring types, but reports no new clinical results.
35 citations
,
April 2006 in “Ocular Surface” This review discusses adverse effects of cosmetic products and procedures on the ocular surface, including mild discomfort to severe vision-threatening conditions, and reports no new clinical results.
33 citations
,
November 2006 in “Survey of Ophthalmology” This report discusses the various causes and clinical assessment of madarosis, emphasizing the importance of recognizing and diagnosing associated vision or life-threatening conditions, without presenting new findings.
32 citations
,
January 2019 in “American Journal of Clinical Dermatology” This review discusses the use of topical minoxidil for various types of alopecia and reports mixed evidence on its efficacy, with stronger support noted for conditions like eyebrow hypotrichosis and chemotherapy-induced alopecia.
32 citations
,
July 2011 in “Facial Plastic Surgery” This review discusses recent surgical and medical advancements in hair restoration techniques but reports no new clinical results.
28 citations
,
January 2015 in “Skin appendage disorders” This study examined children with trichotillomania using a set of specific questions to better understand the condition and aid clinicians who may be unfamiliar with it.
26 citations
,
August 2016 in “Actas Dermo-Sifiliográficas” This study found that men with frontal fibrosing alopecia were more likely to have facial papules, androgenetic alopecia, and body hair loss compared to women, with the average patient age being higher than in other series, potentially explaining these differences.
23 citations
,
April 2021 in “Journal of Clinical Medicine” This review compiles existing data on frontal fibrosing alopecia and highlights the promise of 5-alpha reductase inhibitors as a treatment option, while noting the need for clarity on its cause and progression.
19 citations
,
May 2011 in “Dermatologic Therapy” This article discusses various options for camouflaging hair loss involving the scalp, eyebrows, and eyelashes, and reports no new clinical findings.
16 citations
,
January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This review discusses frontal fibrosing alopecia and reports no clinical results; the authors note that no therapeutic options tested, including corticosteroids, finasteride, and minoxidil, have shown clear benefits.
13 citations
,
March 1990 in “JAMA” This study found that in a small cohort of patients with infections, tumor necrosis factor levels varied, challenging the interpretation that these levels are transient in gram-negative sepsis.
12 citations
,
March 2018 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This article describes a case of frontal fibrosing alopecia in a patient with chronic lichenoid lupus erythematosus and notes the lack of similar documented cases in existing literature.
10 citations
,
July 2019 in “Facial Plastic Surgery Clinics of North America” This article describes refined techniques in facial hair transplantation for increasing demand in restoring eyebrow density in women and achieving fuller beards in men, without presenting new clinical results.
10 citations
,
February 2015 in “Clinics in Dermatology” This article discusses various periocular conditions like madarosis, milphosis, trichomegaly, and dermatochalasis, and highlights their potential link to underlying local and systemic diseases, but reports no new clinical findings.
9 citations
,
August 2018 in “Journal der Deutschen Dermatologischen Gesellschaft” This study provides the most comprehensive review to date of published cases of frontal fibrosing alopecia, emphasizing a notable association with thyroid disease.