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The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

The right amount of retinoic acid is essential for normal hair growth and development.

Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

Type 2 immunity helps control mite growth in hair follicles, preventing damage.

Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.

TGM3 is important for skin and hair structure and may help diagnose cancer.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Thymic mesenchymal cells have unique gene expression that supports their specific functions in the thymus.