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Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Hair cortisol levels can show increased stress during late pregnancy but only for up to six months.

Rosacea is a skin condition with unclear causes, classified into four subtypes.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

Cyproterone acetate is effective for acne but less so for hirsutism and alopecia, with some side effects and quick menstrual cycle recovery after treatment.

Acne affects most teenagers and can continue into adulthood, with various treatments available that show improvement but have concerns like antibiotic resistance and side effects.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Androgens can both increase and decrease hair growth in different parts of the body.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Targeted cancer therapies often cause serious skin problems that need careful management.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Biotinidase deficiency has various symptoms and can be treated with biotin supplements.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Toxic Shock Syndrome mainly affects menstruating women, can recur, and is linked to staph bacteria, with rapid treatment being crucial.

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.