249 citations
,
April 2002 in “The FASEB journal” This study provides evidence that human skin contains genes and enzymes necessary for producing serotonin and melatonin.
203 citations
,
November 1984 in “Journal of the American Academy of Dermatology” This study presents evidence suggesting that androgenetic alopecia is most likely inherited through a polygenic model, challenging the traditional view that it is caused by a simple Mendelian autosomal dominant gene.
201 citations
,
November 2002 in “Annals of internal medicine” This guideline discusses evidence-based recommendations for managing acute migraine attacks and preventing migraines, highlighting effective treatments such as NSAIDs and triptans but reports no new clinical findings.
188 citations
,
February 2023 in “International Journal of Molecular Sciences” This review compiled evidence suggesting that flavonoids may promote skin wound healing due to their anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant properties, while also discussing current limitations and future prospects for these compounds as wound-healing agents.
165 citations
,
August 2013 in “Lasers in Surgery and Medicine” This review discusses the potential mechanisms and evidence supporting low-level laser therapy for stimulating hair growth in men and women, while noting its safety and effectiveness but needing further study on specific parameters.
152 citations
,
April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This study presents evidence that keratitis–ichthyosis–deafness syndrome is caused by a mutation in the connexin 26 gene, expanding the gene's known involvement in various disorders.
127 citations
,
December 2005 in “Experimental Dermatology” This study provides evidence that psychoemotional stress inhibits hair growth in mice by affecting the brain-hair follicle axis, with specific neuropeptides and treatments modulating this effect.
121 citations
,
November 2020 in “Endocrine” This review discusses evidence on androgen sensitivity as a potential factor in COVID-19 disease severity, suggesting that androgen receptor interactions could influence virus entry and progression, and reports no new clinical results.
112 citations
,
April 2009 in “Cochrane library” This review found some evidence suggesting that spironolactone can effectively reduce hirsutism in women but did not support its use for treating acne vulgaris.
103 citations
,
December 2021 in “Journal of biological rhythms” This review discusses recent evidence on how night-shift work affects the circadian system, sleep, and alertness in shift workers, and reports no clinical results; potential impacts on health are considered.
98 citations
,
May 2008 in “British Journal of Dermatology” This review discusses evidence-based guidance for managing primary cicatricial alopecias but reports no new clinical results, highlighting significant gaps in knowledge and the need for more quality trials.
87 citations
,
December 2015 in “Cochrane library” This review observed limited evidence of clinically significant benefits from treatments for acute central serous chorioretinopathy, which often resolves spontaneously, but identified PDT and micropulse laser as the most promising for further trials.
84 citations
,
February 2013 in “Clinica chimica acta” This review presents evidence that correlations exist between hair mineral imbalances and various diseases, though inconsistencies in results highlight the need for standardized preparation methods.
82 citations
,
May 2010 in “PLoS neglected tropical diseases” This study provides quantitative evidence that secondary syphilis is highly endemic in Cali, Colombia, and many untreated patients have high numbers of circulating Treponema pallidum spirochetes.
73 citations
,
June 2008 in “The Journal of Clinical Endocrinology and Metabolism” This study provides further evidence for a genetic basis of PCOS, showing that polycystic ovarian morphology is a marker of inherited biochemical features in families with PCOS.
73 citations
,
July 1956 in “Journal of Investigative Dermatology” This paper provides evidence supporting the formation of new hair follicles in adult humans, building on findings previously demonstrated in rabbits.
72 citations
,
July 2002 in “Journal of Investigative Dermatology” This study provides genetic evidence that desmoglein-1 can compensate for the loss of desmoglein-3 in hair adhesion, supporting the desmoglein compensation hypothesis.
69 citations
,
December 2015 in “BMC plant biology” This study provides evidence that five Hyp-O-GALT genes are crucial for AGP galactosylation and that AGP glycans are vital for various aspects of plant growth and development.
63 citations
,
January 1999 in “The Journal of Clinical Endocrinology & Metabolism” This study found evidence suggesting a potential genetic link between polycystic ovaries and premature male pattern baldness through screening of first-degree relatives of women with polycystic ovary syndrome.
61 citations
,
September 1994 in “Journal of Medical Genetics” This study found strong evidence linking a keratin gene anomaly to pachyonychia congenita, supporting its role in affecting skin, nails, hair, and mucosa.
53 citations
,
July 2018 in “Drug design, development and therapy” This review summarizes existing evidence on the efficacy and safety of JAK inhibitors for treating alopecia areata and emphasizes the need for improved topical formulations.
53 citations
,
August 2014 in “Cochrane library” This review found no evidence supporting the efficacy of methotrexate for inducing remission in active ulcerative colitis compared to placebo or active comparators.
52 citations
,
November 2013 in “Journal of Pain and Symptom Management” This narrative review evaluates evidence that regional hypothermia can reduce oral, hair, eye, and nail complications from chemotherapy, but highlights the need for more research to address study limitations.
51 citations
,
February 2013 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This review examines evidence on metformin's use in treating various skin disorders and discusses associated cutaneous side-effects; it reports no new clinical results.
50 citations
,
September 2016 in “The Journal of Clinical Endocrinology and Metabolism” This study found no evidence of androgen deficiency or decreased peripheral androgen action in men with persistent sexual symptoms after finasteride use, but identified links to depressed mood and abnormal brain function.
49 citations
,
February 2019 in “The Journal of Clinical Endocrinology and Metabolism” This review offers evidence-based recommendations for diagnosing and treating female pattern hair loss, emphasizing clinical assessment and starting treatment with minoxidil, while noting that measurement of certain hormones and vitamins is optional.
44 citations
,
August 1990 in “PubMed” This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.
42 citations
,
August 2022 in “Diagnostics” This review examines existing evidence on PCOS diagnostic criteria for adolescents and underscores the need for accurate definitions, while highlighting limited research, especially regarding adolescents at risk of PCOS.
39 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This article discusses the role of growth hormone, insulin, and IGF-1 in acne development and highlights how diet and syndromic evidence support their involvement, but presents no new clinical findings.
39 citations
,
January 2012 in “Indian Dermatology Online Journal” This article examines the evidence regarding finasteride's sexual side effects and offers recommendations for patient counseling but reports no new clinical findings.