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High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

Hormone therapy for breast cancer often leads to sexual issues like vaginal dryness and decreased libido.

The letter suggests testosterone replacement therapy might worsen COVID-19 outcomes.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The document concludes that specific itchy skin diseases during pregnancy have varying fetal risks and treatments, including corticosteroids and other medications.

Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.

A pregnant woman's skin condition improved after giving birth, possibly due to high estrogen levels during pregnancy.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Low-level light therapy, possibly combined with other treatments, may become a leading hair loss treatment, while hirsutism often worsens with age and lacks preventive options.

Hormonal therapy changes skin and hair in transgender patients, who need better researched dermatologic care.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Pregnancy causes skin changes like darkening, hair thickening, nail changes, and increased risk of skin growths, most of which usually resolve after birth.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

The document concludes that menopause should be seen as a natural part of aging and managed with personalized care and informed choices.

Understanding gender differences and individual patient characteristics is essential for optimal cosmetic surgery outcomes.

Testosterone Replacement Therapy can improve sexual health in postmenopausal women with low sexual desire, but more research is needed on its long-term effects.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

The normal human prostate does not significantly affect blood DHT levels.

The document concludes that low-dose oral contraceptives and hormonal therapies can manage perimenopause symptoms and reduce some health risks, but lifestyle changes and disease screening are also important.

Woodhouse-Sakati syndrome can cause writer's cramp and other varied symptoms, highlighting the importance of genetic testing for diagnosis.

Aging-related hormone changes affect voice quality, especially during puberty, menstruation, pregnancy, and menopause.

Early treatment of acne is crucial to prevent scarring and psychological effects.

More research is needed to find a cure for hair loss after pregnancy.

Current treatments for hair loss from chemotherapy are limited, but new methods are being researched.