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Some breast cancer patients on hormone therapy experience hair loss, and treatments like certain topical inhibitors and supplements may help without harming their cancer prognosis.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Exemestane may protect bones by stimulating osteoblast growth through androgen-related pathways.

Experts recommend thorough medical, sexual, and psychosocial assessments for women's sexual dysfunctions, and suggest individualized treatment plans with regular check-ups. They also mention potential use of estrogen and androgen therapy, but with caution due to safety concerns.

Estrogen therapy can reduce skin aging but has cancer risks.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

Androgen excess disorders in women were effectively treated with spironolactone, estrogen, and dexamethasone.

Estrogen increases blood vessel growth factor production, while testosterone blocks this increase.

Estrogen and prolactin may play bigger roles in female hair loss than previously thought.

Estrogen deficiency, like after menopause or certain surgeries, leads to faster skin aging and health issues.

Estrogen affects how vitamin A is processed in mouse skin, which may impact acne treatment, hair growth, and skin defense.

Anabolic steroids boost muscle growth, SARMs increase muscle mass and bone density without side effects, and myostatin inhibitors block a protein that stops muscle growth, but each has potential risks.

Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.

Long-term estrogen therapy in postmenopausal women can improve certain health markers, hair loss is common regardless of hormone use, stopping estrogen doesn't increase breast cancer risk, smoking does, and a balanced BMI is linked to lower mortality.

Cancer rates are increasing in developed countries, with estrogen, aging, low vitamin D3, and HPV infection as common causes.

New treatments for excessive hair growth in women include insulin modulators and enzyme inhibitors.

Men on 5-alpha-reductase inhibitors might have worse COVID-19 outcomes.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Using 5-alpha-reductase inhibitors, drugs for prostate issues and hair loss, may lead to eye abnormalities in men.

Skin side effects from CDK4/6 inhibitors in breast cancer patients are generally mild and treatable, allowing most patients to continue treatment.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Taking 5-alpha reductase inhibitors does not increase breast cancer risk in men.

5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.