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    Glossary Epithelial Keratins

    Epithelial keratins are a group of fibrous proteins that form a key component of the cytoskeleton in epithelial cells, including those in the hair follicle. They play a crucial role in maintaining the structural integrity and resilience of hair and skin. In the context of hair loss, abnormalities or mutations in keratin genes can lead to conditions such as alopecia or other hair disorders, highlighting their importance in hair biology and health. Key distinguishing characteristics include their ability to form intermediate filaments, which provide mechanical support and protection to cells.

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    1. Induction of Hard Keratin Expression in Non-Nail-Matrical Keratinocytes by Nail-Matrical Fibroblasts through Epithelial-Mesenchymal Interactions Plastic & Reconstructive Surgery · 2003 · 25 citations
    2. Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    3. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    4. Regulation of Keratin 9 in Nonpalmoplantar Keratinocytes by Palmoplantar Fibroblasts Through Epithelial–Mesenchymal Interactions 1999 · 92 citations
    5. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    6. Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis Frontiers in Cell and Developmental Biology · 2025
    7. Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes Wound repair and regeneration · 2015 · 46 citations
    8. Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins British Journal of Dermatology · 2006 · 63 citations
    9. Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    10. Expression of hair-related keratins in a soft epithelium: Subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation Experimental Cell Research · 1989 · 128 citations
    11. Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction Journal of Dermatological Science · 2017 · 35 citations
    12. An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation EMBO Reports · 2018 · 30 citations
    13. ROLE OF STAT3 IN KERATINOCYTE STEM CELLS DURING SKIN TUMORIGENESIS DigtalCommons @ Texas Medical Center Library (Texas Medical Center) · 2012
    14. Choreographing Immunity in the Skin Epithelial Barrier Immunity · 2019 · 57 citations
    15. Activin B Promotes Epithelial Wound Healing In Vivo through RhoA-JNK Signaling Pathway PLOS ONE · 2011 · 38 citations
    16. Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration PubMed Central · 2015
    17. Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration MOJ proteomics & bioinformatics · 2015
    18. M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing PLOS ONE · 2022
    19. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003 · 561 citations
    20. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    21. Androgen‐inducible TGF‐β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth ˜The œFASEB journal · 2002 · 190 citations
    22. Neutrophil gelatinase‐associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin Experimental dermatology · 2002 · 96 citations
    23. Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo11The authors disclosed conflict of interest. 1999 · 79 citations
    24. Specific receptor detection by a functional keratinocyte growth factor-immunoglobulin chimera. 1995 · 66 citations
    25. Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes Experimental Dermatology · 2000 · 58 citations
    26. WNT5A drives interleukin-6-dependent epithelial–mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis Burns & Trauma · 2022 · 56 citations
    27. Epithelial differentiation of human adipose-derived stem cells (hASCs) undergoing three-dimensional (3D) cultivation with collagen sponge scaffold (CSS) via an indirect co-culture strategy Stem Cell Research & Therapy · 2020 · 48 citations
    28. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001 · 45 citations
    29. Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts Journal of cutaneous pathology · 2008 · 43 citations
    30. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017 · 42 citations