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Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.

Substance abuse can cause various skin problems, including marks from injections, sores, premature aging, and increased cancer risk.

PCOS is a hormonal issue in women that is usually treated with birth control pills, metformin, and lifestyle changes, with early treatment helping to reduce complications and improve life quality.

Some drugs can cause skin and hair color changes, often reversible when the drug is stopped.

Healthcare providers need better understanding and cultural sensitivity to improve care for transgender patients with kidney failure needing transplants.

Some drugs can cause reversible hair loss, but certain chemotherapy drugs may lead to permanent hair loss; drugs can also change hair color and texture.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Mutations in certain receptors can cause diseases and offer new treatment options.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Smoking harms skin health, causing slower wound healing, more wrinkles, and worsening some skin conditions, but may protect against certain others.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Women with lichen planopilaris often have thyroid disease, depression, anxiety, and may respond to treatment with slowed disease progression.

Azelaic acid treats acne, rosacea, and hyperpigmentation with minimal side effects.

The document concludes that understanding health requires considering evolutionary perspectives on reproductive fitness, and recognizing the complexity of factors like diet, testosterone, and sexual orientation.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

AP-2α and AP-2β proteins are essential for healthy adult skin and hair.

Current treatments for hair loss from chemotherapy are limited, but new methods are being researched.

Chemotherapy often causes temporary hair loss, which is distressing and needs better treatment and support.

Gefitinib can cause skin problems, diarrhea, and nausea, but rarely causes severe lung disease or hair loss.

Runx genes are important for stem cell regulation and their roles in aging and disease need more research.

CYLD mutations cause a variety of skin tumors with symptoms starting around age 16, and treatments are currently limited.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Hidradenitis suppurativa treatment should be tailored to the individual, with quitting smoking being important.