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Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Researchers found 19 genes important for root hair growth in a plant called Arabidopsis.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Different PIN proteins affect plant root hair growth by changing how auxin is transported.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Fatty acid transport protein 4 is essential for skin and hair development.

Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.

An imbalanced gut and lack of biotin can cause hair loss in mice.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Follistatin helps hair growth and cycling, while activin prevents it.

Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Certain bacteria and fungi are linked to healthy scalps and dandruff, suggesting that the scalp's microbial balance affects its health.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

Nanotechnology in dermatology shows promise for better drug delivery and treatment effectiveness but requires more safety research.

A position effect on the TRPS1 gene causes excessive hair growth in humans and mice.

The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Different harmful mutations in the CDH3 gene cause HJMD, but symptoms vary among individuals.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

Hoxc genes control hair growth through Wnt signaling.

Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.