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    Glossary DNA fragmentation

    breaking of DNA strands into smaller pieces

    DNA fragmentation refers to the breaking of DNA strands into smaller pieces. This can occur naturally during processes like apoptosis (programmed cell death) or can be induced by external factors such as radiation or certain chemicals. In a clinical or research setting, measuring DNA fragmentation can be important for understanding cell health, diagnosing diseases, or assessing the quality of sperm in fertility studies.

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    1. Faculty Opinions recommendation of Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2020
    2. Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis Reproductive Biology and Endocrinology · 2019 · 48 citations
    3. Finasteride-induced secondary infertility associated with sperm DNA damage Fertility and Sterility · 2011 · 36 citations
    4. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells Developmental dynamics · 1994 · 253 citations
    5. Recent advances in understanding and managing male infertility F1000Research · 2019 · 104 citations
    6. Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne Journal of Dermatology · 2010 · 8 citations
    7. Apoptotic cell death in canine hair follicle. PubMed · 2005 · 5 citations
    8. Inhibition of 5-Alpha Reductase Attenuates Cardiac Oxidative Damage in Obese and Aging Male Rats via the Enhancement of Antioxidants and the p53 Protein Suppression Chemico-Biological Interactions · 2024
    9. 287 Mackerel fermented fish oil suppresses human keratinocyte damage caused by ultraviolet B radiation Journal of Investigative Dermatology · 2017
    10. PD05-10 COMPARATIVE EFFECTS OF FINASTERIDE AND DUTASTERIDE ON SEMEN PARAMETERS IN YOUNG MEN WITH ANDROGENIC ALOPECIA: A RANDOMIZED CONTROLLED STUDY The Journal of Urology · 2026
    11. Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study Journal of Endocrinological Investigation · 2022 · 46 citations
    12. Secondary infertility due to use of low-dose finasteride International Urology and Nephrology · 2012 · 15 citations
    13. Effects of High-dose Radioactive Iodine Therapy on Hormonal Profiles and Sperm Quality in Thyroidectomy Patients Molecular Imaging and Radionuclide Therapy · 2026
    14. Finasteride Reactions Weekly · 2013
    15. 285 A new scalp treatment for anti-ageing hair Journal of Investigative Dermatology · 2017
    16. Forensic DNA phenotyping: the need for proportionate regulation and judicial clarity in law enforcement Egyptian Journal of Forensic Sciences · 2026
    17. Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy? Andrology · 2026
    18. Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia European Journal of Pharmacology · 2001 · 28 citations
    19. Impact of Microbial Infection on Sperm Parameters of Seminal Bacteria in Asymptomatic Subfertile Males Urogenital tract infection · 2023
    20. A Simple Method to Extract DNA from Hair Shafts Using Enzymatic Laundry Powder PLoS ONE · 2013 · 8 citations
    21. Single-strand DNA breaks in human hair root cells exposed to mobile phone radiation International Journal of Radiation Biology · 2012 · 37 citations
    22. Geranyl Acetate Attenuates Para-phenylenediamine-induced Cytotoxicity, DNA Damage, Apoptosis, and Inflammation in HaCaT Keratinocytes Iranian journal of pharmaceutical research · 2025 · 1 citations
    23. Araliadiol Protects Human Keratinocytes From Oxidative Stress, DNA Damage, and Apoptosis via Activation of Antioxidant Signaling Frontiers in Bioscience-Landmark · 2026
    24. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner Cell Death & Differentiation · 2016 · 42 citations
    25. Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization Oxidative Medicine and Cellular Longevity · 2022 · 20 citations
    26. Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis Archives of Toxicology · 2018 · 215 citations
    27. Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: An in vitro study Journal of Ethnopharmacology · 2011 · 50 citations
    28. PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair Frontiers in Cell and Developmental Biology · 2021 · 9 citations
    29. Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model Cancers · 2022 · 8 citations
    30. Cyproterone Acetate: A Genotoxic Carcinogen? Pharmacology & Toxicology · 2001 · 1 citations