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    Glossary CXCL2

    small signaling protein that attracts immune cells to inflammation

    CXCL2, also known as Macrophage Inflammatory Protein 2 (MIP-2), is a type of chemokine—a small signaling protein involved in the immune response. It plays a crucial role in attracting neutrophils, a type of white blood cell, to sites of inflammation or injury, thereby aiding in the body's defense mechanisms.

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    1. CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17 The Journal of Experimental Medicine · 2024 · 32 citations
    2. Mechanical stimuli-induced CCL2 restores adult mouse cells to regenerate hair follicles Molecular Therapy — Nucleic Acids · 2023 · 18 citations
    3. Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population Genetics and Molecular Research · 2015 · 8 citations
    4. CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata International Journal of Molecular Sciences · 2024
    5. Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis Cancer Research · 2008 · 70 citations
    6. Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study British Journal of Dermatology · 2004 · 58 citations
    7. The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles Differentiation · 2009 · 57 citations
    8. Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata Annals of Dermatology · 2019 · 17 citations
    9. Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing Frontiers in Immunology · 2024 · 7 citations
    10. Combination of an engineered <i>Lactococcus lactis</i> expressing CXCL12 with light‐emitting diode yellow light as a treatment for scalded skin in mice Microbial biotechnology · 2021 · 6 citations
    11. Th1 Chemokine CXCL10 and Alopecia Areata: The Possible Target for the Treatment of Alopecia Areata Journal of Clinical & Cellular Immunology · 2016 · 3 citations
    12. Insights into the context-dependent immunological roles of the CXCL12–CXCR4 axis in alopecia Frontiers in Immunology · 2026
    13. Hypoxia-Derived Mesenchymal Stem Cell Exosomes Downregulate CXCL12 and Upregulate IL-10 Expression in a Murine Model of Androgenic Alopecia Molecular and Cellular Biomedical Sciences · 2026
    14. Gene expression of FOXA1 and CCL2 in different phenotypes of infertile women with polycystic ovarian syndrome Egyptian Journal of Basic and Applied Sciences · 2025
    15. Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration Cell Reports · 2025
    16. CXCL12 Drives Reversible Fibroimmune Remodeling in Androgenetic Alopecia Revealed by Single-Cell RNA Sequencing International Journal of Molecular Sciences · 2025
    17. EVALUATION OF THE ROLE OF CXCL12 IN CASES OF ALOPECIA AREATA ALEXMED ePosters · 2025
    18. Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup International Journal of Molecular Sciences · 2024
    19. CXCL12 inhibits hair growth through CXCR4 Biomedicine & Pharmacotherapy · 2022
    20. Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice Experimental and Therapeutic Medicine · 2017
    21. Correlation Analysis of CXCL10, FOS, HOXC13, and WNT4 Gene Polymorphisms with Key Economic Traits—Initial Population Screening for Jiangnan Cashmere Goats Genes · 2025
    22. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015 · 236 citations
    23. Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid and Saw Palmetto Extract Evidence-based Complementary and Alternative Medicine · 2009 · 22 citations
    24. The crosstalk of monocyte-neutrophil in hair follicles regulates neutrophil transepidermal migration in contact dermatitis Communications Biology · 2025 · 6 citations
    25. Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case–Control Study The application of clinical genetics · 2019 · 6 citations
    26. The homing of exogenous hair follicle mesenchymal stem cells into hair follicle niches JCI Insight · 2023 · 6 citations
    27. Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    28. Granulocyte colony stimulating factor promotes scarless tissue regeneration Cell Reports · 2024 · 4 citations
    29. Deep skin fibroblast-mediated macrophage recruitment supports acute wound healing 2024 · 3 citations
    30. PRF Lysates Modulate Chemokine Expression in Oral Squamous Carcinoma and Healthy Epithelial Cells Bioengineering · 2024 · 2 citations